AI Article Synopsis
- * Results showed that higher coffee consumption was linked to increased left ventricular mass and atrial volume, while also correlating with a reduced risk of specific arrhythmias such as atrial fibrillation.
- * Interestingly, the way individuals metabolize caffeine (measured by certain genetic factors) did not seem to influence these heart-related associations, suggesting that current caffeine consumption limits for heart health may not be needed.
Article Abstract
Background: The association of coffee intake and caffeine metabolism with arrhythmias and cardiac structure is not fully understood.
Objective: We aim to explore the associations of coffee intake and caffeine metabolism with the risk of certain types of arrhythmias, a broad range of cardiovascular imaging phenotypes, and a potential gene-coffee interaction.
Methods: On the basis of the UK Biobank imaging study, heart metrics were extracted via cardiovascular magnetic resonance using machine learning. Caffeine metabolism was determined by cytochrome P4501A2 gene (CYP1A2) or a polygenetic score of different genetic variants influencing caffeine metabolism. Genome-wide association data for 2-sample Mendelian randomization originated predominantly from individuals of European descent.
Results: A total of 34,992 individuals (mean age 63.5 ± 7.5 years; 52.9% female) were assessed in the principal imaging analysis. Higher daily consumption of coffee was independently associated with higher left ventricular mass, larger global ventricular volume, higher ventricular stroke volume, and larger atrial volume. The results were further supported by Mendelian randomization analysis. CYP1A2 and genetic score for caffeine metabolism were not associated with cardiovascular measurements (P>.053 for all tests). Coffee consumption was associated with a lower risk of sinus rhythm with short PR (per cup increase: odds ratio 0.90; 95% confidence interval 0.82-0.99) and atrial fibrillation (odds ratio 0.89; 95% confidence interval 0.84-0.93).
Conclusion: Coffee consumption was associated with a lower risk of atrial fibrillation, increased left ventricular mass, elevated ventricular volume, and larger atrial volume. Caffeine metabolism did not significantly alter the association. Our results suggest that customary caffeine consumption limitations aimed at arrhythmia risk reduction might be unnecessary.
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| http://dx.doi.org/10.1016/j.hrthm.2024.11.047 | DOI Listing |
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