Recent advances in discovery and functional analysis of the small proteins and microRNA expressed by polyomaviruses.

Virology

Lewis Katz School of Medicine at Temple University, Department of Microbiology, Immunology and Inflammation Center for Neurovirology and Gene Editing, 3500 N. Broad Street, Philadelphia, PA, 19140, USA. Electronic address:

Published: January 2025

AI Article Synopsis

  • * Some polyomaviruses can cause serious diseases such as polyomavirus-associated nephropathy, progressive multifocal leukoencephalopathy, trichodysplasia spinulosa, and Merkel cell carcinoma.
  • * Recent research focuses on the functions of viral proteins and microRNA that these viruses express, shedding light on their role in viral biology, how they transform cells, and their potential impact on disease progression.

Article Abstract

The polyomavirus family consists of a highly diverse group of small DNA viruses isolated from various species, including humans. Some family members have been used as model systems to understand the fundamentals of modern biology. After the discovery of the first two human polyomaviruses (JC virus and BK virus) during the early 1970s, their current number reached 14 today. Some family members cause considerably severe human diseases, including polyomavirus-associated nephropathy (PVAN), progressive multifocal leukoencephalopathy (PML), trichodysplasia spinulosa (TS) and Merkel cell carcinoma (MCC). Polyomaviruses encode universal regulatory and structural proteins, but some members express additional virus-specific proteins and microRNA, which significantly contribute to the viral biology, cell transformation, and perhaps progression of the disease that they are associated with. In the current review, we summarized the recent advances in discovery, and functional and structural analysis of those viral proteins and microRNA.

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Source
http://dx.doi.org/10.1016/j.virol.2024.110310DOI Listing

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