The epidemiologic associations of food availability with national incidence and disability rates of idiopathic pediatric epilepsy.

Background: The epidemiology of idiopathic pediatric epilepsy globally continues to be defined. To date there has been no evaluation of how national food availability may associate with the incidence and disability-adjusted life years (DALYs) lost from this condition. Correspondingly, the aim of this study was to define if such associations exist.

Methods: Incidence and DALY rates of pediatric patients with idiopathic epilepsy were abstracted by country from the Global Burden of Disease database. Data regarding food availability parameters were identified and abstracted from the Food Systems Dashboard database. Associations were tested using univariate and multivariate regression analyses.

Results: There were sufficient data in a total of 175 countries. Mean incidence rate and DALYs lost across these countries were 62.3 per 100,000 and 189.2 per 100,000 respectively. Across all countries, higher incidence rates of idiopathic pediatric epilepsy were statistically associated with lower supply of nuts and seeds (P = 0.04), and higher prevalence of moderate or severe food insecurity (P = 0.03). Similarly, higher DALYs lost due to idiopathic pediatric epilepsy were statistically associated with lower supply of fish (P = 0.03), higher supply of starchy roots (P = 0.03), and higher prevalence of moderate or severe food insecurity (P < 0.01). When categorizing countries based on income-status, there was a decrease and divergence in significant associations found between high income versus low-middle income countries.

Conclusions: There are many possible novel associations between national food availability and the incidence rate and DALYs lost due to idiopathic pediatric epilepsy across the world, which may be more pronounced and divergent based on income.