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Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances.
Mol Cell
January 2025
Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. Electronic address:
By building synthetic regulatory landscapes, Jensen et al. and Thomas et al. demonstrate in this issue of Molecular Cell that gene expression levels strongly depend on the genomic distance between enhancers and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.
View Article and Find Full Text PDFSelf-reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities.
Addiction
January 2025
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
Background And Aims: The opioid crisis continues to exert a tremendous toll in North America, with existing interventions often falling short of addressing ongoing needs. Psychedelics are emerging as a possible alternative therapy for mental health and substance use disorders. This study aimed to gather insights on how people use or are considering using psychedelics to manage opioid use disorder (OUD), how these experiences are perceived to impact opioid use and what these lessons imply for future research and practice.
View Article and Find Full Text PDFImproving breast cancer treatments using pharmacomicrobiomics.
mBio
January 2025
Center for Gastrointestinal Biology and Disease and Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Tamoxifen is the mainstay treatment for estrogen-positive breast cancer for over half a century. However, a significant proportion of patients experience disease recurrence due to treatment failure attributed to various factors, including disease pathology, genetics, and drug metabolism. Alam et al.
View Article and Find Full Text PDFDevelopment of the Whole Day Matters Toolkit for Primary Care: a consensus-building study to mobilize national public health guidelines in practice.
Health Promot Chronic Dis Prev Can
January 2025
School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Introduction: Strategic knowledge mobilization efforts are needed to enhance uptake and use of the Canadian 24-Hour Movement Guidelines (24HMG), which describe optimal amounts of physical activity, sedentary behaviour and sleep each day for overall health. The Whole Day Matters Toolkit for Primary Care is an evidence-informed resource to help primary care providers (PCPs) disseminate the 24HMGs. The purpose of this study was to describe gaining consensus on toolkit components through iterative revisions to improve its utility in preparation for the September 2022 launch, and to summarize early dissemination efforts.
View Article and Find Full Text PDFValue attributes of advanced therapy medicinal products: a documentary analysis of comments received from stakeholders during reimbursement decisions to England's national institute of health and care excellence.
Expert Rev Pharmacoecon Outcomes Res
January 2025
Comprehensive Clinical Trials Unit, University College London, UK.
Objectives: Advanced therapy medicinal products (ATMPs) are transformative healthcare interventions, however, there has been limited research exploring their value. The objective of this study was to conduct a thematic analysis as part of a documentary analysis to identify value attributes of ATMPs.
Methods: As part of the NICE assessment processes in England, stakeholders are invited to provide comments on the technology.
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