AI Article Synopsis
- The study evaluates the short-term effectiveness of denervation as a treatment for hypertension, specifically targeting patients who have not been on medication.
- An analysis of four studies with a total of 752 participants showed that denervation significantly lowered both ambulatory and office blood pressure compared to a sham procedure, with no major safety issues reported.
- While the results are promising for those who can't or choose not to use drug therapy, further research is needed to explore the long-term effects of denervation and to include a larger, more extended patient follow-up.
Article Abstract
Background: To evaluate the short-term efficacy of denervation in treating hypertension with the exclusion of drug-interfering factors.
Methods: An electronic search was conducted across 8 databases, including MEDLINE, PubMed, Cochrane Library, and EMBASE, for articles on denervation in the treatment of medication-naïve hypertension published from inception to May 2024. All data were meta-analyzed using RevMan 5.3 software.
Results: Four studies, comprising a total of 752 subjects, were screened according to the inclusion and exclusion criteria. Meta-analysis indicated that, compared to the sham-operated group, the denervation group showed a significant reduction in short-term 24-hour ambulatory systolic blood pressure and office systolic blood pressure (OSBP) as well as office diastolic blood pressure (ODBP). No significant safety events were identified.
Conclusion: Denervation has the potential to reduce blood pressure in the short-term for patients with medication-naïve hypertension, demonstrating an acceptable safety profile. This offers hope for patients who are intolerant to drug therapy or unwilling to take lifelong medication. However, its long-term effects require further study. Future research should focus on expanding the sample size and prolonging the follow-up period to further solidify its role in the treatment of hypertension.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608684 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000040705 | DOI Listing |
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