AI Article Synopsis
- This review focuses on how pulsed electric fields can selectively cause cardiac injury during atrial fibrillation ablation, with a look at both preclinical and clinical studies.
- Recent findings show that pulsed electric fields lead to greater injury to heart tissue (myocardium) compared to other tissues, and that the complication rates from this method are lower than those using radiofrequency and cryoballoon ablation.
- While pulsed field ablation is promising due to its selective effects on heart tissue, some complications still arise, indicating the need for more research to enhance its safety and effectiveness.
Article Abstract
Purpose Of Review: This review examines the selective cardiac injury induced by pulsed electric fields during atrial fibrillation ablation. It consolidates findings from both preclinical and clinical studies on cardiac selectivity and explores the potential mechanisms behind this selectivity.
Recent Findings: Preclinical studies indicate that pulsed electric fields cause significantly more myocardial injury compared with other tissues. Clinical studies have similarly shown that complication rates for pulsed field ablation are notably lower than those for radiofrequency and cryoballoon ablation.
Summary: Pulsed field ablation demonstrates a notable selectivity for myocardial injury, likely because of the unique functional and metabolic characteristics of cardiomyocytes. This review delves into the underlying principles of cardiac selectivity and proposes future directions for improving this selectivity. It is important to note that while pulsed field ablation shows promise, its cardiac selectivity is not absolute, as some complications still occur, necessitating further research.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623377 | PMC |
| http://dx.doi.org/10.1097/HCO.0000000000001183 | DOI Listing |
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