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[Corrigendum] Anti‑carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane‑induced colonic aberrant crypt foci formation in rats. | LitMetric

[Corrigendum] Anti‑carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane‑induced colonic aberrant crypt foci formation in rats.

Int J Oncol

Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Hem-Onc Section, PC Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Published: January 2025

AI Article Synopsis

Article Abstract

Following the publication of the above article, an interested reader drew to the authors' attention that certain of the in vitro image panels shown in Fig. 3B (featuring the effects of adding five different concentrations of omeprazole on acridine orange/ethidium bromide‑stained HCA‑7 cells) and Fig. 4 (showing western blotting experiments) on p. 173 and 174 respectively contained overlapping data panels, where results that were intended to represent the results of differently performed experiments had apparently been derived from the same original sources. Specifically, the image panels for 0 and 50 µM/ml omeprazole (Fig. 3Ba and Bb), and 100 and 200 µM/ml omeprazole (Fig. 3Bc and Bd), in Fig. 3B were strikingly similar; and the bands shown for p21 and cyclin A in Fig. 4A and B respectively were also similar, albeit each set of protein bands were turned through 180° relative to the other. After having examined their original data, the authors realized that these figures had been inadvertently assembled incorrectly. The revised versions of Figs. 3 (showing the data correctly for the 0, 100 and 300 µM/ml omeprazole experiments) and 4 (with the cyclin A data omitted) are shown on the next page. Note that the edits made to these figures do not affect the overall results and conclusions reported in the paper. The authors are grateful to the Editor of for granting them the opportunity to publish this corrigendum, and all the authors agree with its publication; furthermore, they apologize to the readership of the journal for any inconvenience caused. [International Journal of Oncology 40: 170‑175, 2012; DOI: 10.3892/ijo.2011.1214].

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637503PMC
http://dx.doi.org/10.3892/ijo.2024.5709DOI Listing

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