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Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients.

Clin Cosmet Investig Dermatol

December 2024

Division of Dermatology, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Vitiligo is a common disease. Limited studies in Saudi Arabia have explored the detailed clinical characteristics of vitiligo, as outlined in recent consensus reports by vitiligo experts.

Objective: To determine vitiligo prevalence and detailed clinical characteristics in a Saudi cohort.

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Background: Research on evaluating the efficacy of non-cultured epidermal cell suspension (NCECS) combined with excimer lamps for the treatment of vitiligo is currently unavailable. This research aims to evaluate the efficacy of this combination in treating vitiligo.

Methods: A prospective, controlled study was conducted from November 2021 to January 2024.

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Background: Vitiligo is a clinically prevalent acquired skin disorder characterized by depigmentation. Currently, the therapeutic options for vitiligo are restricted, and numerous issues exist, such as a prolonged treatment course, unsatisfactory therapeutic efficacy, adverse reactions, and a high propensity for recurrence after treatment cessation.

Aim: To assess the safety and efficacy of combined treatment involving oral tofacitinib citrate (TC) and a 308-nm excimer laser (EL), with the aim of discovering a rapid and effective treatment approach to minimize the side effects of various drugs.

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Article Synopsis
  • * The disease is complex and involves immune responses where CD8+ T-cells target melanocytes, and various treatment strategies include phototherapy, grafting, and new drugs like JAK-STAT inhibitors.
  • * Future research should focus on exploring alternative drug targets, genetic factors, and immune cell treatments, potentially leading to more effective and lasting solutions for vitiligo.
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