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Photocrosslinking and capture for the analysis of carbohydrate-dependent interactions.
Bioorg Med Chem Lett
December 2024
Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:
Carbohydrates play crucial roles in biological systems, including by mediating cell and protein interactions. The complexity and transient nature of carbohydrate-dependent interactions pose significant challenges for their characterization, as traditional techniques often fail to capture these low-affinity binding events. This review highlights the increasing utility of photocrosslinkers in studying carbohydrate-mediated interactions.
View Article and Find Full Text PDFAngiogenesis, a key point in the association of gut microbiota and its metabolites with disease.
Eur J Med Res
December 2024
Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Shandong University, Jinan, 250021, Shandong, China.
The gut microbiota is a complex and dynamic ecosystem that plays a crucial role in human health and disease, including obesity, diabetes, cardiovascular diseases, neurodegenerative diseases, inflammatory bowel disease, and cancer. Chronic inflammation is a common feature of these diseases and is closely related to angiogenesis (the process of forming new blood vessels), which is often dysregulated in pathological conditions. Inflammation potentially acts as a central mediator.
View Article and Find Full Text PDFThe effects of risk preferences on consumers' reference-dependent choices for autonomous vehicles.
Risk Anal
December 2024
University of Liverpool Management School, University of Liverpool, Liverpool, UK.
Advances in artificial intelligence (AI) are reshaping mobility through autonomous vehicles (AVs), which may introduce risks such as technical malfunctions, cybersecurity threats, and ethical dilemmas in decision-making. Despite these complexities, the influence of consumers' risk preferences on AV acceptance remains poorly understood. This study explores how individuals' risk preferences affect their choices among private AVs (PAVs), shared AVs (SAVs), and private conventional vehicles (PCVs).
View Article and Find Full Text PDFCommunity Assembly Mechanisms of nirK- and nirS-type Denitrifying Bacteria in Sediments of Eutrophic Lake Taihu, China.
Curr Microbiol
December 2024
Marine Synthetic Ecology Research Center, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Marine Science, Guangdong Provincial Observation and Research Station for Marine Ranching in Lingdingyang Bay, China-ASEAN Belt and Road Joint Laboratory On Mariculture Technology, State Key Laboratory for Biocontrol, Sun Yat-sen University, Zhuhai, 519082, China.
Denitrifying bacteria, particularly nirK- and nirS-type, are functionally equivalent and could occupy different niches, but their community assembly mechanisms and responses to environmental heterogeneity are poorly understood in eutrophic lakes. In this study, we investigated the community assembly mechanisms of nirK- and nirS-type denitrifying bacteria and clarified their responses to sediments environmental factors in Lake Taihu, China. The quantitative real-time PCR and Illumina HiSeq-based sequencing revealed that the abundance and composition of two types of denitrifying bacterial communities varied among different sites in the sediments of Lake Taihu.
View Article and Find Full Text PDFUnderstanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review.
Diabetol Metab Syndr
December 2024
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Obesity is a multifactorial condition influenced by genetic, environmental, and microbiome-related factors. The gut microbiome plays a vital role in maintaining intestinal health, increasing mucus creation, helping the intestinal epithelium mend, and regulating short-chain fatty acid (SCFA) production. These tasks are vital for managing metabolism and maintaining energy balance.
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