Localized high probe density greatly improves the signaling stability of supramolecular electrochemical aptamer-based (Supra-EAB) sensors.

Chem Commun (Camb)

State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.

Published: December 2024

AI Article Synopsis

  • DNA aptamers are being developed as effective tools for creating biosensors.
  • The main method for adjusting the density of these probes has been through changing DNA concentrations.
  • Researchers created a new type of sensor, called Supra-EAB, which allows for higher localized probe densities and enhances stability against enzymes.

Article Abstract

DNA aptamers have emerged as a promising class of probes for the development of biosensors. However, the only viable strategy thus far for adjustment of probe densities is tuning DNA concentrations. Herein, we constructed a class of Supra-EAB sensors to introduce localized high probe densities and achieved significantly improved stability against enzymes.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d4cc05396fDOI Listing

Publication Analysis

Top Keywords

localized high
8
high probe
8
supra-eab sensors
8
probe densities
8
probe density
4
density greatly
4
greatly improves
4
improves signaling
4
signaling stability
4
stability supramolecular
4

Similar Publications

Poultry scientists are constantly studying different breeds of cockerels that would be suitable for capon meat production. Capon meat, although not yet very popular, is characterized by exceptional taste qualities that could appeal to many customers. Obtaining the appropriate palatability, structure and tenderness of capon meat is possible thanks to the reduction in androgen levels following the castration of roosters.

View Article and Find Full Text PDF

Background: Long-term use of levodopa, a metabolic precursor of dopamine (DA) for alleviation of motor symptoms in Parkinson's disease (PD), can cause a serious side effect known as levodopa-induced dyskinesia (LID). With the development of LID, high-frequency gamma oscillations (~100 Hz) are registered in the motor cortex (MCx) in patients with PD and rats with experimental PD. Studying alterations in the activity within major components of motor networks during transition from levodopa-off state to dyskinesia can provide useful information about their contribution to the development of abnormal gamma oscillations and LID.

View Article and Find Full Text PDF

Controlling the nucleation, growth, and dissolution of Li is crucial for the high cycling stability in rechargeable Li metal batteries. The overpotential for Li nucleation (η) on Li alloys such as Li-Au is generally lower than that on metal current collectors (CCs) with very limited Li solubility like Cu. However, the alloying process of CC and its impact on the Li nucleation kinetics remain unclear.

View Article and Find Full Text PDF

Chemically Induced Dimerization via Nanobody Binding Facilitates in Situ Ligand Assembly and On-Demand GPCR Activation.

JACS Au

December 2024

Laboratory of Bioorganic Chemistry, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.

Methods that enable the on-demand synthesis of biologically active molecules offer the potential for a high degree of control over the timing and context of target activation; however, such approaches often require extensive engineering to implement. Tools to restrict the localization of assembly also remain limited. Here we present a new approach for stimulus-induced ligand assembly that helps to address these challenges.

View Article and Find Full Text PDF

Background: Prostate cancer (PCa) was the most common noncutaneous cancer among Nigerian men in 2020. Despite this high incidence, documented rates may be an underestimation.

Objectives: This study aimed to determine the hospital incidence rate, trends, and characterise the clinicopathologic features, and treatment outcomes of patients with PCa in our institution.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!