Multi-material design optimization problems can, after discretization, be solved by the iterative solution of simpler sub-problems which approximate the original problem at an expansion point to first order. In particular, models constructed from convex separable first order approximations have a long and successful tradition in the design optimization community and have led to powerful optimization tools like the prominently used method of moving asymptotes (MMA). In this paper, we introduce several new separable approximations to a model problem and examine them in terms of accuracy and fast evaluation. The models can, in general, be nonconvex and are based on the Sherman-Morrison-Woodbury matrix identity on the one hand, and on the mathematical concept of topological derivatives on the other hand. We show a surprising relation between two models originating from these two-at a first sight-very different concepts. Numerical experiments show a high level of accuracy for two of our proposed models while also their evaluation can be performed efficiently once enough data has been precomputed in an offline stage. Additionally it is demonstrated that suboptimal decisions can be avoided using our most accurate models.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602833PMC
http://dx.doi.org/10.1007/s12220-024-01663-0DOI Listing

Publication Analysis

Top Keywords

topological derivatives
8
design optimization
8
models
6
efficient accurate
4
accurate separable
4
separable models
4
models discretized
4
discretized material
4
optimization
4
material optimization
4

Similar Publications

Activity of the mammalian DNA transposon piggyBat from Myotis lucifugus is restricted by its own transposon ends.

Nat Commun

January 2025

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Members of the piggyBac superfamily of DNA transposons are widely distributed in host genomes ranging from insects to mammals. The human genome has retained five piggyBac-derived genes as domesticated elements although they are no longer mobile. Here, we have investigated the transposition properties of piggyBat from Myotis lucifugus, the only known active mammalian DNA transposon, and show that its low activity in human cells is due to subterminal inhibitory DNA sequences.

View Article and Find Full Text PDF

Background: Ortholog prediction, essential for various genomic research areas, faces growing inconsistencies amidst the expanding array of ortholog databases. The common strategy of computing consensus orthologs introduces additional arbitrariness, emphasizing the need to examine the causes of such inconsistencies and identify proteins susceptible to prediction errors.

Results: We introduce the Signal Jaccard Index (SJI), a novel metric rooted in unsupervised genome context clustering, designed to assess protein similarity.

View Article and Find Full Text PDF

The pluripotent stem cell (PSC)-derived human primordial germ cell-like cells (PGCLCs) are a cell culture-derived surrogate model of embryonic primordial germ cells. Upon differentiation of PSCs to PGCLCs, multiple loci of HML-2, the hominoid-specific human endogenous retrovirus (HERV), are strongly activated, which is necessary for PSC differentiation to PGCLCs. In PSCs, strongly activated loci of HERV-H family HERVs create chromatin contacts, which are required for the pluripotency.

View Article and Find Full Text PDF

Thermodynamic Behavior of Doped Graphene: Impact of Heavy Dopant Atoms.

Entropy (Basel)

December 2024

Departamento de Física, Universidad de La Serena, Casilla 554, La Serena 1700000, Chile.

This study investigates the effect of incorporating heavy dopant atoms on the topological transitions in the energy spectrum of graphene, as well as on its thermodynamic properties. A tight-binding model is employed that incorporates a lattice composition parameter associated with the dopant's effect to obtain the electronic spectrum of graphene. Thus, the substitutional atoms in the lattice impact the electronic structure of graphene by altering the connectivity of the Dirac cones and the symmetry of the energy surface in their spectrum.

View Article and Find Full Text PDF

Topological indices, derived from molecular graphs, provide valuable numerical descriptors for the comprehensive analysis of pharmaceuticals. These indices are pivotal in the physicochemical characterization and predictive assessment of various drugs. In this study, we calculate several degree-based topological indices for a range of migraine treatment medications, including aspirin, caffeine, eletriptan, ergotamine, sumatriptan, rizatriptan, verapamil, diclofenac, frovatriptan, and droperidol.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!