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Introduction: This study aimed to investigate the impact of the blood flow restriction bladder type (single- [SC-BFR] vs. multi-chambered [MC-BFR]) on exercise performance, cardiovascular responses, and perceptual experiences with exercise sessions incorporating multiple sets to volitional failure in a randomized, crossover experimental design.
Methods: Twenty-seven healthy, physically active participants (age: 22.6 ± 5.7; weight: 74.3 ± 15.8 kg; height: 171.7 ± 7.7 cm; BMI: 25.0 ± 4.1 kg/m2; ∼93% reported regular resistance training within 6 months; 11 females) randomly performed exercise to failure (4× sets to failure, 20% 1RM, 1 min rest between sets) in each of three conditions: SC-BFR (using the Delfi Personalized Tourniquet Device inflated to 60% limb occlusion pressure), MC-BFR (using the B Strong Cuffs inflated to 300 mmHg according to manufacturer recommendations), and N-BFR (no BFR control).
Results: SC-BFR blunted post-exercise increases in carotid-femoral pulse wave velocity ( = 0.328) (+3.3%) whereas the other conditions showed elevations (MC-BFR +11.8% [ = 0.041], N-BFR +9.3% [ = 0.012]). Discomfort was lower in N-BFR compared to SC-BFR ( < 0.001) and MC-BFR ( = 0.035) but all displayed similar exertion ( = 0.176). Median total repetitions achieved were significantly less in SC-BFR (57 [25-75th percentile: 47-65) than MC-BFR (76 [63-91] ( = 0.043) and N-BFR [106 (97-148)] = 0.005). Per set repetition volumes were similar on set 1 between SC-BFR ( < 0.001) and MC-BFR ( = 0.001) and were lower than N-BFR ( ≤ 0.001) whereas in sets 2-4, MC-BFR performed similar number of repetitions as N-BFR ( = 0.984-1.000).
Conclusion: Bladder design of a BFR cuff has an impact on the acute responses to exercise if applied according to recommended application guidelines, as SC-BFR impacts performance to a greater degree and mitigates post-exercise arterial stiffness responses compared to MC-BFR and N-BFR while both BFR conditions display greater levels of discomfort compared to N-BFR.
Clinical Trial Registration: NCT06276673.
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http://dx.doi.org/10.3389/fspor.2024.1469356 | DOI Listing |
J Neurotrauma
December 2024
Department of Medical Sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.
This study compared the roles of extraparenchymal autonomic nervous system (ANS) control of cerebral blood flow (CBF) versus intraparenchymal cerebrovascular autoregulation in 487 patients with aneurysmal subarachnoid hemorrhage (SAH) and 413 patients with traumatic brain injury (TBI). Vasomotion intensity of extraparenchymal and intraparenchymal vessels were quantified as the amplitude of oscillations of arterial blood pressure (ABP) and intracranial pressure (ICP) in the very low frequency range of 0.02-0.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Pediatrics, Children's Cancer Research Center, Kinderklinik München Schwabing, TUM School of Medicine, Technical University of Munich, Munich, Germany.
Introduction: Pediatric sarcomas, including osteosarcoma (OS), Ewing sarcoma (EwS) and rhabdomyosarcoma (RMS) carry low somatic mutational burden and low MHC-I expression, posing a challenge for T cell therapies. Our previous study showed that mediators of monocyte maturation sensitized the EwS cell line A673 to lysis by HLA-A*02:01/CHM1-specific allorestricted T cell receptor (TCR) transgenic CD8 T cells (CHM1 CD8 T cells).
Methods: In this study, we tested a panel of monocyte maturation cytokines for their ability to upregulate immunogenic cell surface markers on OS, EwS and RMS cell lines, using flow cytometry.
Front Neurol
December 2024
Department of Neurosurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Background: Cerebral arteriovenous malformations (AVMs) are intricate vascular anomalies that disrupt normal cerebral blood flow, potentially leading to severe neurological complications. Although the pathology of AVMs is not fully understood, epigenetic mechanisms have been implicated in their formation.
Methods: Transcriptional differences between cerebral AVMs and normal tissues were analyzed using RNA sequencing (RNA-seq), identifying IGF2BP2 as a key differentially expressed gene.
Se Pu
January 2025
School of Public Health, Wuhan University, Wuhan 430071, China.
Industrialization has led to significant increases in the types and quantities of pollutants, with environmental pollutants widely present in various media, including the air, food, and everyday items. These pollutants can enter the human body via multiple pathways, including ingestion through food and absorption through the skin; this intrusion can disrupt the production, release, and circulation of hormones in the body, resulting in a range of illnesses that affect the reproductive, endocrine, and nervous systems. Consequently, these pollutants pose substantial risks to human health.
View Article and Find Full Text PDFMil Med
December 2024
Emergency Response Team, Ukrainian Red Cross, Vyshgorod, Kyiv 07301, Ukraine.
This case study presents the successful treatment of a 26-year-old male who experienced profuse bleeding from a gunshot wound to his thigh 4 days after the initial injury. The patient underwent surgery performed by a military vascular surgeon, during which previously undetected injuries to the femoral artery and vein were identified. The surgeon conducted a femoral artery alloprosthesis and sutured the damaged femoral vein.
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