Advanced Squamous Cell Carcinoma in the Paratracheal Region: Navigating Diagnosis and Comprehensive Treatment Challenges.

This case of a paratracheal mass emphasizes the importance of early detection and flexibility in the treatment planning for advanced squamous cell carcinoma, especially when logistical challenges impact access to care. A 69-year-old woman presented with a four-month history of progressive dysphagia, significant weight loss, and the recent onset of stridor, suggesting potential airway obstruction. Imaging studies revealed a large heterogeneous mass in the superior mediastinum, extending from the base of the neck into the thoracic inlet. The mass measured approximately 6.9 cm × 3.4 cm, involving the trachea and upper esophagus, causing significant compression and deviation. Additional findings included small hypermetabolic lymph nodes in the mediastinum. The patient underwent bronchoscopy and endoscopy, which revealed narrowing but no intraluminal lesions, indicating external compression by the mass. The pathological examination confirmed well-differentiated squamous cell carcinoma, characterized by keratinization and positive p40 immunostaining, with negative p16 immunostaining, indicating a non-HPV-related etiology. An urgent tracheostomy was performed to secure the airway, which the patient tolerated well. Following this, inpatient chemotherapy with a regimen of Taxotere, Cisplatin, and 5-fluorouracil (TPF) was initiated to manage the tumor and prevent further complications. This case required a multidisciplinary approach to address the patient's complex clinical presentation, including surgical, oncological, and supportive care. As confirmed by imaging, the lack of distant metastasis suggests a potentially better prognosis if effective local control can be achieved. The integrated care provided was essential in managing the patient's immediate and long-term health needs.