AI Article Synopsis
- The study investigates the connection between osteosarcopenia, a condition combining bone and muscle loss, and COVID-19 mortality in hospitalized patients in Bushehr, Iran, highlighting the increased risks associated with this syndrome in older adults.
- Out of 4,173 participants, 297 were hospitalized for COVID-19, with 80 fatalities; those with osteosarcopenia showed significantly higher mortality rates and increased risk for severe outcomes like ICU admission.
- The findings suggest that assessing musculoskeletal issues like osteosarcopenia in older COVID-19 patients could serve as an early warning for potential severe illness and help guide patient management.
Article Abstract
Background: It has been documented that old age and chronic diseases are associated with poor prognosis and mortality among COVID-19 patients. Osteosarcopenia is a geriatric syndrome with a considerable prevalence which increases morbidity and mortality. This study investigated the relationship between COVID-19 mortality and osteosarcopenia and its parameters in-hospitalized patients in Bushehr, Iran.
Methods: In this retrospective cohort study, participants of the Bushehr Elderly Health (BEH) program who were hospitalized due to COVID-19 between 1st March 2020 and 23rd September 2021 were assessed. Osteosarcopenia was considered as the presence of both osteopenia/osteoporosis and sarcopenia. We used the Cox proportional hazards model to identify the association between oteosarcopenia and the risk of COVID-mortality in 2442 person-days.
Results: Among 4173 participants,297 patients were in-hospitalized due to COVID-19. We found that 80(26.94%) patients expired due to COVID-19 during the follow-up period. Osteosarcopenia and its parameters were more prevalent in patients who expired. The incidence rate of mortality among osteosarcopenic patients was 5.04(3.43- 7.40) per 100 person-days. In the Cox proportional hazards models, osteosarcopenia and its parameters increase the risk of COVID-mortality [Osteosarcopenia: HR:1.73(1.00-3.01), sarcopenia: HR:1.72(1.00-2.99), Osteoporosis: HR:2.67(1.53-4.67), Low muscle mass: HR:1.90(1.05-3.46), low muscle strength: HR:1.80(1.03-3.16), and low gait speed: HRadj:2.39(1.31-4.38). The ORs of ICU admission and use of invasive mechanical ventilation among osteosarcopenic patients and its parameters were higher than those without it.
Conclusions: This study identified the impact of osteosarcopenia and its parameters on the mortality of in-hospitalized patients with COVID-19. Assessment of musculoskeletal disorders could help in early warning of older patients with severe COVID-19.
Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-024-01443-1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599644 | PMC |
| http://dx.doi.org/10.1007/s40200-024-01443-1 | DOI Listing |
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