Objective: The aging demographic landscape worldwide portends a heightened prevalence of neurodegenerative disorders. Foremost among these is Alzheimer's disease (AD), the foremost cause of dementia in older adults. The shortage of efficacious therapies and early diagnostic indicators underscores the imperative to identify non-invasive biomarkers for early detection and disease monitoring. Recently, blood metabolites have emerged as promising candidates for AD biomarkers.
Methods: Leveraging nuclear magnetic resonance (NMR) spectroscopy on plasma specimens, we conducted a cross-sectional study encompassing 35 AD patients and 35 age-matched healthy controls. Cognitive function was evaluated using the mini-mental state examination in all participants, followed by peripheral blood sample collection. We utilized univariate and multivariate analyses to perform targeted lipidomic profiling via NMR spectroscopy.
Results: Our study revealed significant differences in the expression profiles of low-density lipoprotein-associated subfractions in females and high-density lipoprotein-associated subfractions in males between AD patients and healthy controls (all p<0.05). However, there was no significant metabolite overlap between males and females. Furthermore, receiver operating characteristic curve analysis demonstrated that the combination of lipid metabolites had good diagnostic values (all area under the curve>0.70; p<0.05).
Conclusion: Our findings suggest that the blood plasma samples using NMR hold promise in distinguishing between AD patients and healthy controls, with significant clinical implications for advancing AD diagnostic methodologies.
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http://dx.doi.org/10.30773/pi.2024.0164 | DOI Listing |
J Fluoresc
December 2024
Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah, 61001, Iraq.
In the present work, a diazonium salt is prepared by a diazonium reaction of sulfamerazine in the presence of aqueous hydrochloric acid and sodium nitrate. Structural confirmation of azo compounds synthesize is achieved by mass spectrometry, infrared spectroscopy, and H, C nuclear magnetic resonance. The sample geometry is derived using Density Functional Theory (DFT) and DT-DFT applied to the basis set B3LYPL6-311 + G(d,p).
View Article and Find Full Text PDFJ Pharm Sci
December 2024
Egyptian Petroleum Research Institute, 1 Ahmed El-Zomor Street, El Zohour Region, Nasr City, Cairo 11727, Egypt. Electronic address:
Clinical diagnostics and biological research are advanced by magnetic theranostic, which uses macromolecule-based magnetic theranostic agents for targeted therapy and diagnostic imaging. Within this review, the interaction of magnetic nanoparticles (MNPs) with biological macromolecules will be covered. The exciting potential of macromolecule-based magnetic theranostic agents to be used as a tool in drug delivery, photothermally therapy (PTT), gene therapy, hyperthermia therapy and photodynamic therapy (PDT) will be discussed.
View Article and Find Full Text PDFMagn Reson Imaging
December 2024
Department of Nuclear Magnetic Resonance, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China; Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou 730030, China. Electronic address:
Purpose: To explore the feasibility of Deep learning radiomics nomograms (DLRN) in predicting IDH genotype.
Methods: A total of 402 glioma patients from two independent centers were retrospectively included, and the data from center I was randomly divided into a training cohort (n = 239) and an internal validation cohort (n = 103) on a 7:3 basis. Center II served as an independent external validation cohort (n = 60).
Food Chem
December 2024
College of Food Science and Nutritional Engineering, China Agricultural University; National Engineering Research Center for Fruit & Vegetable Processing; Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs; Beijing Key Laboratory for Food Non-thermal Processing, Beijing 100083, China. Electronic address:
The effect of thermal processing on the binding between methional and chelated-soluble pectin obtained from muskmelon was investigated. Particle size measurements demonstrated that the formed complex between methional and chelated-soluble pectin exhibited small sizes after thermal processing. Pyrene fluorescence analysis showed that the interaction between methional and pectin occurred in the hydrophilic region.
View Article and Find Full Text PDFAdv Mater
December 2024
Centre for Advanced Structural Ceramics, Department of Materials, Imperial College London, London, SW7 2AZ, UK.
Inorganic/inorganic composites are found in multiple applications crucial for the energy transition, from nuclear reactors to energy storage devices. Their microstructures dictate their properties from mass transport to fracture resistance. Consequently, there has been a multitude of processes developed to control them, from powder mixing and the use of short or long fibers, to tape casting for laminates up to recent 3D printing.
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