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Cerebral spinal fluid analyses and therapeutic implications for leptomeningeal metastatic disease.
J Neurooncol
December 2024
Department of Medicine, University of Toronto, Toronto, ON, Canada.
Purpose: To review applications of cerebral spinal fluid (CSF) biomarkers for the diagnosis, monitoring and treatment of leptomeningeal metastatic disease (LMD) among patients with metastatic solid tumors.
Methods: A narrative review identified original research related to CSF biomarkers among patients with metastatic solid tumors and LMD. Pre-clinical research (e.
XX World Congress of Stereotactic and Functional Neurosurgery: The Meeting Summary.
World Neurosurg
November 2024
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.
Why so slow? The advancement of females in neurosurgery: a 30-year analysis.
J Neurosurg Pediatr
November 2024
2Division of Neurosurgery, Children's Hospital Los Angeles, California; and.
Objective: As gender parity in medicine improves, neurosurgery lags behind. In pediatric neurosurgery, considered the most "female-friendly" subspecialty, determining the extent to which gender disparity has evolved over time, and how it compares to other subspecialties, can serve as an important benchmark for neurosurgery altogether. This study analyzed gender parity across different neurosurgical and subspecialty training stages to understand how female representation varies with training level and leadership positions.
View Article and Find Full Text PDFRadioresistance and brain metastases: a review of the literature and applied perspective.
Front Oncol
October 2024
Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Intracranial metastatic disease is a serious complication of cancer, treated through surgery, radiation, and targeted therapies. The central role of radiation therapy makes understanding the radioresistance of metastases a key interest for prognostication and therapeutic development. Although historically defined clinic-radiographically according to tumour response, developments in new techniques for delivering radiation treatment and understanding of radioprotective mechanisms led to a need to revisit the definition of radioresistance in the modern era.
View Article and Find Full Text PDFMagnetic resonance imaging techniques for monitoring glioma response to chemoradiotherapy.
J Neurooncol
January 2025
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Purpose: Treatment response assessment for gliomas currently uses changes in tumour size as measured with T- and T-weighted MRI. However, changes in tumour size may occur many weeks after therapy completion and are confounded by radiation treatment effects. Advanced MRI techniques sensitive to tumour physiology may provide complementary information to evaluate tumour response at early timepoints during therapy.
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