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Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome.
Int J Mol Sci
December 2024
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
Barth Syndrome (BTHS) is an early onset, lethal X-linked disorder caused by a mutation in tafazzin (TAFAZZIN), a mitochondrial acyltransferase that remodels monolysocardiolipin (MLCL) to mature cardiolipin (CL) and is essential for normal mitochondrial, cardiac, and skeletal muscle function. Current gene therapies in preclinical development require high levels of transduction. We tested whether TAFAZZIN gene therapy could be enhanced with the addition of a cell-penetrating peptide, penetratin (Antp).
View Article and Find Full Text PDFTransendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1.
Microbiol Spectr
December 2024
Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.
Despite its importance in pathogenesis, the hematogenous dissemination pathway of is still largely uncharacterized. To probe the molecular details of transendothelial migration more easily, we studied this process using cultured primary or telomerase-immortalized human microvascular endothelial cells in a medium that maintains both the human cells and the spirochetes. In -infected monolayers, we observed ~55% of wild-type spirochetes crossing the monolayer.
View Article and Find Full Text PDFPaired and solitary ionocytes in the zebrafish olfactory epithelium.
bioRxiv
November 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921.
The sense of smell is generated by electrical currents that are influenced by the concentration of ions in olfactory sensory neurons and mucus. In contrast to the extensive morphological and molecular characterization of sensory neurons, there has been little description of the cells that control ion concentrations in the zebrafish olfactory system. Here, we report the molecular and ultrastructural characterization of zebrafish olfactory ionocytes.
View Article and Find Full Text PDFElectrical impedance sensing in stem cell research: Insights, applications, and future directions.
Prog Biophys Mol Biol
November 2024
Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, 616, Sultanate of Oman. Electronic address:
The exceptional differentiation abilities of stem cells make them ideal candidates for cell replacement therapies. Considering their great potential, researchers should understand how stem cells interact with other cell types. The production of high-quality differentiated cells is crucial for favorable treatment and makes them an ideal choice for clinical applications.
View Article and Find Full Text PDF[Acute hyperkalemia management].
Rev Med Liege
November 2024
Service de Néphrologie, Dialyse et Transplantation, CHU Liège, Belgique.
Article Synopsis
- * The speed at which potassium levels increase is crucial because quicker changes can lead to severe and potentially life-threatening symptoms; thus, acute hyperkalemia requires immediate treatment.
- * Although there's no universal standard for measuring the severity of hyperkalemia, electrocardiogram (ECG) changes are important indicators; this article discusses current knowledge and suggests a management approach for acute cases.
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