AI Article Synopsis
- - Gangliosides are important for functions in nerve cells, influencing processes like growth, communication, and degeneration.
- - Research indicated that mice given gangliosides made from glucosylceramide experienced heightened sensitivity to touch, known as mechanical allodynia.
- - The study found that using glucosylceramide inhibitors helped decrease this sensitivity during inflammation in mice, highlighting the potential of targeting gangliosides for pain relief.
Article Abstract
Gangliosides play pivotal roles in neuronal tissue processes, such as axonal elongation, synaptic transmission, and neuronal degeneration. Several studies have shown that mice injected with gangliosides synthesized from glucosylceramide exhibit mechanical allodynia. Thus, we hypothesized that glucosylceramide synthase inhibitors affect nociceptive behavior. We investigated the analgesic effect of intrathecal glucosylceramide inhibition on bilateral allodynia caused by prolonged unilateral hind paw inflammation in mice. Repeated administration of a glucosylceramide inhibitor reduced mechanical allodynia in both inflamed and non-inflamed hind paws. These results suggested that ganglioside reduction is critical for analgesia during inflammatory pain.
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| http://dx.doi.org/10.1016/j.jphs.2024.10.003 | DOI Listing |
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Article Synopsis
- - Gangliosides are important for functions in nerve cells, influencing processes like growth, communication, and degeneration.
- - Research indicated that mice given gangliosides made from glucosylceramide experienced heightened sensitivity to touch, known as mechanical allodynia.
- - The study found that using glucosylceramide inhibitors helped decrease this sensitivity during inflammation in mice, highlighting the potential of targeting gangliosides for pain relief.
UDP-glucose ceramide glucosyltransferase specifically upregulated in plasmacytoid dendritic cells regulates type I interferon production upon CpG stimulation.
Biochem Biophys Res Commun
November 2024
Core Research Facilities, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Plasmacytoid dendritic cells (pDCs) are a distinct subset of DCs involved in immune regulation and antiviral immune responses. Recent studies have elucidated the metabolic profile of pDCs and reported that perturbations in amino acid metabolism can modulate their immune functions. Glycolipid metabolism is suggested to be highly active in pDCs; however, its significance remains unclear.
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