Genomic analysis and characterization of a new Salmonella phage vB_Sen_ST2 infecting Salmonella enterica serovars Typhi and Typhimurium.

Microb Pathog

Unidad Periférica de Investigación Básica y Clínica en Enfermedades Infecciosas, Departamento de Salud Pública/División de Investigación, Facultad de Medicina, UNAM, C.P. 04510, Mexico City, Mexico; Laboratorio de Patogenicidad Bacteriana, Unidad de Hemato-Oncología e Investigación. Hospital Infantil de México Federico Gómez/Facultad de Medicina UNAM, C.P. 06720, Mexico City, Mexico. Electronic address:

Published: January 2025

AI Article Synopsis

  • Researchers have sequenced and characterized a new virus called Salmonella phage vB_Sen_ST2, which is part of the Kuttervirus genus.
  • This phage specifically targets the Salmonella enterica serovars Typhi and Typhimurium, which cause salmonellosis, a common foodborne illness.
  • The genome of this phage is made up of 156,028 base pairs of double-stranded DNA, showing promise as a potential treatment option for controlling these harmful bacteria.

Article Abstract

In this study, we have characterized and sequenced the whole genome of a new member of the Kuttervirus genus, Salmonella phage vB_Sen_ST2. This phage selectively targets Salmonella enterica serovars Typhi and Typhimurium, which are major etiologic agents of salmonellosis worldwide. Its genome consists of a linear, double-stranded DNA of 156,028 bp, with a G + C content of 44.93 %. Based on our results, Salmonella phage vB_Sen_ST2 presents suitable features to be considered as a potential control agent against Salmonella enterica serovars that are responsible for salmonellosis.

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Source
http://dx.doi.org/10.1016/j.micpath.2024.107178DOI Listing

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