AI Article Synopsis
- Accurate localization of brain motor areas is crucial for safeguarding motor function during neurosurgery, and this study evaluates the use of OPM-MEG technology for this purpose in patients with brain tumors and healthy individuals.
- The study involved comparing OPM-MEG and 3T-fMRI in localizing primary motor areas, validating results through intraoperative electrical stimulation.
- Results showed that both techniques successfully mapped motor areas, with OPM-MEG providing more centralized activation signals, suggesting its potential as a reliable tool in neurosurgical procedures and research.
Article Abstract
Background: Accurately localizing brain motor areas is vital for protecting motor function during neurosurgical procedures. Magnetoencephalography (MEG) based on optically pumped magnetometer (OPM) improves the availability of MEG in clinical applications. The aim of this study is to evaluate the availability, accuracy and precision of "OPM-MEG" for localizing motor areas in brain tumor patients and healthy individuals.
Methods: Participants were enrolled and subjected to primary motor area localization by both 3T-fMRI and 128-channel OPM-MEG examinations. The localization accuracy (ability of mapping on the anatomical location) and precision (activation signal centralization) were compared between the two methods, and accuracy was further validated by intraoperative direct cortical electrical stimulation (DCS) on the localized area with assistance of neuro-navigation system.
Result: A total of 12 participants (7 brain tumor patients and 5 healthy individuals) were enrolled and all had successful localization for motor areas by both methods. The average time of OPM-MEG examination for each limb function was approximately 9 min. The localizations by both methods mainly covered the anatomical location of primary motor cortex and were partially overlapped. The motor activation signal identified by OPM-MEG was more centralized than fMRI did. The centroid of motor area localized by the OPM-MEG deviated from it by fMRI, with a mean distance of 19.7 mm and 27.48 mm for hand or foot localization, respectively. Furthermore, the OPM-MEG centroid for hand movement successfully triggered corresponding hand response by DCS.
Conclusions: In this first-in-human study exploring the potential of OPM-MEG in functional localization of motor areas, we revealed its availability and reliability in mapping motor areas, demonstrating it as a promising tool in assisting neurosurgical practice and neuroscience research.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuroimage.2024.120953 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.
Ann Neurol
January 2025
Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Objective: Approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Epidemiological data have identified traumatic brain injury (TBI) as an exogenous risk factor for ALS; however, the mechanisms by which TBI may worsen SOD1 ALS remain largely undefined.
Methods: We sought to determine whether repetitive TBI (rTBI) accelerates disease onset and progression in the transgenic SOD1 mouse ALS model, and whether loss of the primary regulator of axonal degeneration sterile alpha and TIR motif containing 1 (Sarm1) mitigates the histological and behavioral pathophysiology.
Patterns of Cerebellar-Cortical Structural Covariance Mirror Anatomical Connectivity of Sensorimotor and Cognitive Networks.
Hum Brain Mapp
January 2025
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that individual differences in structure should be related, especially for connected regions.
View Article and Find Full Text PDFStructure-function coupling alterations in cognitively normal individuals with white matter hyperintensities.
J Alzheimers Dis
January 2025
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: White matter hyperintensities (WMH) are prominent neuroimaging markers of cerebral small vessel disease (CSVD) linked to cognitive decline. Nevertheless, the pathophysiological mechanisms underlying WMH remain unclear.
Objective: This study aimed to assess the structural decoupling index (SDI) as a novel metric for quantifying the brain's hierarchical organization associated with WMH in cognitively normal older adults
Methods: We analyzed data from 112 cognitively normal individuals with varying WMH burdens (43 high WMH burden and 69 low WMH burden).
Managing sleep issues in Parkinson's disease: an up-to-date review.
Expert Rev Neurother
January 2025
Department of Neurology, Dokkyo Medical University, Mibu, Japan.
Introduction: In Parkinson's disease (PD), sleep-wake problems are disease-related symptoms that occur throughout the day and have a negative impact on patients' quality of life to an extent that is equal to or greater than that of typical motor symptoms.
Areas Covered: Insomnia due to fragmented sleep and excessive daytime sleepiness (EDS) worsen as PD progresses. Nighttime wearing-off and early morning-off should be considered first when fragmented sleep is reported in PD patients.
Domain-Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach.
Brain Behav
January 2025
Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Purpose: Due to the highly individualized clinical manifestation of Parkinson's disease (PD), personalized patient care may require domain-specific assessment of neurological disability. Evidence from magnetic resonance imaging (MRI) studies has proposed that heterogenous clinical manifestation corresponds to heterogeneous cortical disease burden, suggesting customized, high-resolution assessment of cortical pathology as a candidate biomarker for domain-specific assessment.
Method: Herein, we investigate the potential of the recently proposed Mosaic Approach (MAP), a normative framework for quantifying individual cortical disease burden with respect to a population-representative cohort, in predicting domain-specific clinical progression.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!