Background: The Frontal Assessment Battery (FAB) is widely used to assess executive dysfunction in patients with amnestic mild cognitive impairments due to Alzheimer's disease (aMCI-AD), but its neurobiological meaning is unclear. To elucidate this, we examined the relationship between the FAB score and three key imaging biomarkers: gray matter volume, amyloid-beta (Aβ) deposition, and glucose metabolism.
Methods: Twenty Aβ- and tau-positive aMCI-AD patients and age-matched controls underwent structural magnetic resonance imaging and positron emission tomography with [C]PiB and [F]FDG. Voxel-based morphometry and statistical parametric mapping analyses were performed to elucidate the relationships between FAB scores and regional gray matter volume, [C]PiB uptake for Aβ deposition, and [F]FDG uptake for glucose metabolism.
Results: FAB scores were significantly lower in aMCI-AD than in controls (p < 0.001). In aMCI-AD, FAB was significantly correlated with right inferior frontal gray matter volume and right medial and left middle frontal glucose metabolism (family-wise error p < 0.05). However, there was no correlation between Aβ deposition and FAB (family-wise error p < 0.05).
Conclusions: The decreased FAB score is linked more with frontal-lobe neurodegeneration than with Aβ pathology in aMCI-AD. The FAB could be an early marker for neurodegeneration related to frontal-lobe executive dysfunction.
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http://dx.doi.org/10.1016/j.jns.2024.123327 | DOI Listing |
J Neuroeng Rehabil
December 2024
Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, 400044, P.R. China.
Background: Neural activation induced by upper extremity robot-assisted training (UE-RAT) helps characterize adaptive changes in the brains of poststroke patients, revealing differences in recovery potential among patients. However, it remains unclear whether these task-related neural activities can effectively predict rehabilitation outcomes. In this study, we utilized functional near-infrared spectroscopy (fNIRS) to measure participants' neural activity profiles during resting and UE-RAT tasks and developed models via machine learning to verify whether task-related functional brain responses can predict the recovery of upper limb motor function.
View Article and Find Full Text PDFMagn Reson Imaging
December 2024
Department of Neurology, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China. Electronic address:
Introduction: More and more evidence suggesting that internal carotid artery stenosis is not only a risk factor for ischemic stroke but also for cognitive impairments. Hypoperfusion and silent micro emboli have been reported as the pathophysiological mechanisms causing cognitive impairment. The effect of carotid artery stenting (CAS) on cognitive function varied from study to study.
View Article and Find Full Text PDFAm J Orthod Dentofacial Orthop
December 2024
Department of Orthodontics, Sivas Cumhuriyet University Faculty of Dentistry, Sivas, Turkey. Electronic address:
Introduction: This study aimed to evaluate maxillary dental midline shifts and mandibular asymmetries created in different amounts and directions on photographs taken from 7 different angles by different groups and to determine acceptable esthetic limits.
Methods: Photographs of a female model in a social smile position were taken from 7 different angles (0° [frontal], 15°, 30°, and 45° on the right and left sides) and digitally modified for maxillary dental and mandibular midline deviations at specified degrees using Adobe Photoshop. To enable participants to evaluate the photographs sequentially, the photographs were transformed into videos using Adobe Premiere Pro software.
Alzheimers Res Ther
December 2024
Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Cyceron, Boulevard Henri Becquerel, BP 5229, 14074, Caen Cedex, France.
Background: Accumulation of critically short telomeres (CST) is implicated in decreased tissular regenerative capacity and increased susceptibility to degenerative diseases such as Alzheimer's disease (AD). Telomere shortening has also been associated with age-related brain changes. However, it remains unclear whether CST accumulation is directly associated with AD markers or instead amplifies age-related effects, potentially increasing susceptibility of developing AD in cognitively healthy older adults.
View Article and Find Full Text PDFChin J Integr Med
December 2024
Department of Spine, The Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, 310053, China.
Objective: To elucidate how spinal manipulative therapy (SMT) exerts its analgesic effects through regulating brain function in lumbar disc herniation (LDH) patients by utilizing resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: From September 2021 to September 2023, we enrolled LDH patients (LDH group, n=31) and age- and sex-matched healthy controls (HCs, n=28). LDH group underwent rs-fMRI at 2 distinct time points (TPs): prior to the initiation of SMT (TP1) and subsequent to the completion of the SMT sessions (TP2).
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