AI Article Synopsis
- iTBS (intermittent theta burst stimulation) shows potential in improving working memory and other symptoms in individuals with schizophrenia, but more research is needed to understand its mechanisms.
- A study with 48 schizophrenia patients involved 20 sessions of iTBS or sham treatment, followed by cognitive assessments and brain scans to evaluate brain connectivity.
- Results indicated that patients receiving active iTBS had improved symptoms and increased connectivity between specific brain regions, highlighting iTBS as a promising approach to address cognitive deficits in schizophrenia.
Article Abstract
Background: Although intermittent theta burst stimulation (iTBS) has shown effectiveness in addressing working memory (WM) deficits in individuals with schizophrenia (SZ), the current body of evidence is limited and the specific mechanisms involved remain unclear. Therefore, this pilot fMRI study aimed to examine the efficacy of parietal iTBS in ameliorating WM impairments and explore its influence on the resting-state effective connectivity within the frontoparietal network in patients with SZ.
Method: A total of 48 patients diagnosed with SZ were randomly assigned to an active or sham iTBS group and underwent 20 sessions of active or sham iTBS over 4 weeks. Subsequently, all patients underwent cognitive tests, clinical symptom assessments, and resting-state functional MRI (rs-fMRI) scans. The effective connectivity between the frontal and parietal brain regions during the rs-fMRI scans was analyzed using a spectral dynamic causal modeling approach. Additionally, this trial was registered at the Chinese Clinical Trial Registry in November 2022 (registry number: ChiCTR2200057286).
Results: iTBS treatment improved the positive symptoms, negative symptoms, general psychopathology, and WM deficits. Following the iTBS intervention, the active group demonstrated a significant increase in connectivity strengths from the right MFG to the right SPL (p = 0.031) and from the left SPL to the left MFG (p = 0.010) compared to the pre-treatment levels. Additionally, compared to the sham group, the active group displayed a significantly higher connectivity strength from the right MFG to the right SPL (p = 0.042) after iTBS treatment.
Conclusion: All these findings suggest that iTBS targeting the parietal region may influence the resting-state effective connectivity within the frontoparietal network, thereby offering promising therapeutic implications for alleviating the cognitive deficits in SZ.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638604 | PMC |
| http://dx.doi.org/10.1016/j.nicl.2024.103715 | DOI Listing |
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