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PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Tissue Cell
January 2025
Anesthesia Surgery Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region 830000, China.
Background: Postoperative cognitive dysfunction (POCD) is a postoperative complication that can be induced by anaesthesia. PCSK9 has been shown to have a role in neuronal development and apoptosis. However, PCSK9 has not been studied in sevoflurane-induced POCD-related disorders.
View Article and Find Full Text PDFEffect of Clonidine on Duration of High-Volume, Low-Concentration Caudal Epidurals.
Cureus
December 2024
Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, USA.
Article Synopsis
- Caudal blocks are a pediatric anesthesia technique used to manage pain after circumcision; this study aimed to compare the duration of the block when using a high-volume, low-concentration (HVLC) local anesthetic with and without the addition of clonidine.
- The study included 129 children aged 0-3 years and measured the effectiveness of pain relief based on how long patients waited before needing additional acetaminophen; no significant differences were found between the clonidine and no-clonidine groups regarding pain management or emergence agitation.
- Overall, the addition of clonidine did not significantly improve the outcomes of HVLC caudal blocks for children undergoing circumcision.
A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.
J Neurophysiol
February 2025
Department of Anesthesiology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People's Republic of China.
Article Synopsis
- Insomnia has a genetic component (22-25% heritability), but key genetic regions influencing its risk are not well understood.
- Researchers utilized advanced methods like UTMOST and TWAS, combined with data from a large GWAS of over 462,000 Europeans and gene expression data, to study insomnia-related genes.
- The study identified two new susceptibility genes (VRK2 and MMRN1) linked to insomnia, found specific brain regions enriched with related SNPs, and highlighted important biological pathways that could lead to future treatment options.
Exosomal PVRL4 Promotes Lung Adenocarcinoma Progression by Enhancing the Generation of Myeloid-Derived Suppressor Cell-Secreted TGF-β1.
Thorac Cancer
January 2025
Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Background: The cancer cell marker poliovirus receptor-like protein 4 (PVRL4) has been shown to be highly expressed in many cancers, including lung cancer. Myeloid-derived suppressor cells (MDSCs) are a population of immature myeloid cells with immunosuppressive roles that can attenuate the anticancer response. Here, the precise functions and the relationship between PVRL4 and MDSCs in lung adenocarcinoma (LUAD) progression were investigated.
View Article and Find Full Text PDFCase report: A case of giant malignant solitary fibrous tumor of the pleura with Doege-Potter's syndrome and review of the literature.
Front Oncol
November 2024
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
The solitary fibrous tumor of the pleura (SFTP) is a rare intrathoracic neoplasm that commonly originates from the subpleural mesenchymal cells of the visceral pleura and accounts for less than 5% of all pleural tumors. We reported a case of a 54-year-old man with a two-week history of hypoglycemia, a six-month history of productive cough and fatigue, and chronic right chest pain. Radiological techniques revealed a giant intra-thoracic mass with hypervascularization, and pathological staining was carried out to make a definitive diagnosis of SFTP.
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