AI Article Synopsis
- The study investigates the safety of fluorescent nanoparticles (FNPs) from roasted duck by examining their effects on PC12 cells and the worm C. elegans.
- Exposure to FNPs increased early apoptosis, altered cell cycles, raised reactive oxygen species, and decreased mitochondrial function in PC12 cells, while C. elegans showed growth and behavior changes without significant mortality.
- The findings contribute to understanding FNP safety and provide guidance for assessing risks in food consumption containing these nanoparticles.
Article Abstract
Background: The safety of fluorescent nanoparticles (FNPs) that enter the human body through food consumption is uncertain. In this study, the biocompatibility of FNPs derived from roast duck was investigated using pheochromocytoma (PC12) cells and Caenorhabditis elegans.
Results: Fluorescent nanoparticles, at concentrations of 1 and 4 mg mL, caused an increase in early apoptosis, altered the cell cycle, elevated reactive oxygen species levels, and decreased mitochondrial membrane potential in PC12 cells. Both acute and prolonged exposure to the FNPs enabled them to permeate C. elegans via its food source, accumulating predominantly in the intestine. At concentrations ranging between 0 and 15 mg mL, FNPs did not induce mortality in C. elegans but they did affect its growth, reproductive ability, and motor behavior.
Conclusion: This study advances the understanding of FNP safety significantly, facilitates risk assessment for foods containing FNPs, and provides valuable guidance to ensure food safety. © 2024 Society of Chemical Industry.
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| http://dx.doi.org/10.1002/jsfa.14052 | DOI Listing |
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