Little is known about the role of peripheral Neuropeptide Y (NPY) in regulating energy homeostasis. A recent study published in by Zhu et al. demonstrates that NPY released by sympathetic nerve terminals in the adipose tissue stimulates the proliferation of thermogenic adipocytes. The findings may shed new light on the mechanisms that link sympathetic NPY and obesity.
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Sympathetic NPY Boosts Thermogenic Adipocytes.
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Center for Hypothalamic Research and Department of Internal medicine, UT Southwestern, Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390 USA.
Little is known about the role of peripheral Neuropeptide Y (NPY) in regulating energy homeostasis. A recent study published in by Zhu et al. demonstrates that NPY released by sympathetic nerve terminals in the adipose tissue stimulates the proliferation of thermogenic adipocytes.
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Neuropeptide Y (NPY) is a powerful orexigenic factor in the brain. However, mice lacking NPY or NPY receptor Y1 (NPY1R) have minimal changes in basal food intake. In a study published in Nature, Zhu et al.
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Article Synopsis
- * Researchers used microneurography to measure muscle sympathetic nerve activity in six healthy adults during both resting conditions and after administering dexmedetomidine, an α-adrenergic agonist.
- * Findings indicate that increased sympathetic neuronal activity (like AP discharge and recruitment patterns) is positively correlated with higher levels of NPY and norepinephrine, highlighting their role in maintaining vascular health.
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