AI Article Synopsis
- Angiotensin II type-1 receptor antibody (AT1R-Ab) is being investigated for its role in both acute and chronic antibody-mediated rejection (AMR) in organ transplants.
- There is ongoing debate regarding previous literature in light of the new Banff AMR diagnostic classification system and updated histocompatibility testing guidelines from the STAR workgroup.
- This review highlights the latest insights into how AT1R-Ab contributes to transplant rejection, clinical evidence supporting its harmful effects, and laboratory testing techniques used to detect it.
Article Abstract
Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving Banff AMR diagnostic classification system and refinement of recommendations for histocompatibility testing by the Sensitization in Transplantation Assessment of Risk (STAR) workgroup. This mini-review discusses the latest understanding of pathophysiological mechanisms, clinical evidence for the pathogenicity of AT1R-Ab, and methods of laboratory testing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598415 | PMC |
| http://dx.doi.org/10.3389/ti.2024.13280 | DOI Listing |
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