AI Article Synopsis
- Red blood cells play a crucial role in hemostasis, but recent experiments reveal an unexpected inverse correlation between hematocrit levels and the maximum amplitude measured by thromboelastogram (TEG).
- A comprehensive review at a single institution analyzed 7,176 TEG samples taken shortly after hematocrit measurements, using both mechanical and acoustic TEG systems.
- Findings show that higher hematocrit is linked to lower maximum amplitude readings, indicating that TEG may not accurately reflect the role of red blood cells in normal blood clotting.
Article Abstract
Red blood cells are critical participants in normal hemostasis, but experiments have shown that the thromboelastogram (TEG) maximum amplitude has a paradoxical inverse relationship with hematocrit. This study reviewed all samples at a single academic institution where any mechanical (TEG 5000) or acoustic (TEG 6s) TEG was drawn within 5 min of hematocrit measurement. A total of 7,176 samples were identified using complete TEG and conventional coagulation test data (6,384 mechanical, 744 acoustic, and 48 both). In the primary analysis, hematocrit was negatively associated with the maximum amplitude on both mechanical and acoustic platforms after adjusting for relevant confounders. This suggests that the thromboelastogram may misrepresent the contribution of red blood cells in normal hemostasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598428 | PMC |
| http://dx.doi.org/10.3389/fmed.2024.1421727 | DOI Listing |
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