Each year, a substantial number of global deaths are attributed to secondhand smoke (SHS) exposure, with children representing a significant proportion of these fatalities. This systematic review evaluates the effects of passive smoking, or SHS, on children's health outcomes, focusing on respiratory conditions, behavioral issues, cognitive impairment, growth retardation, and immune system effects. A comprehensive literature search was conducted from July 5 to July 18, 2024, across multiple databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Following the set inclusion and exclusion guidelines, 12 studies were chosen for the review, and their quality was measured using the Newcastle-Ottawa Scale. The findings indicate a strong association between SHS exposure and adverse health outcomes in children, including increased rates of asthma, low birth weight, and behavioral problems. Additionally, smoke-free legislation appears to mitigate some of these harmful effects, though results vary across different regions and populations. The review underscores the urgent need for effective smoking cessation strategies and improved healthcare communication to protect children from the dangers of passive smoking.
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http://dx.doi.org/10.7759/cureus.72548 | DOI Listing |
J Gastrointest Cancer
December 2024
Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Shenzhen University (People's Hospital of Shenzhen Baoan District), Shenzhen, 518100, China.
Background And Objective: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Despite advances in treatment, metastatic colorectal cancer (mCRC) remains a significant challenge due to its heterogeneity and resistance to therapy. Regorafenib, a multikinase inhibitor, can inhibit tumor progression through multiple mechanisms, thereby improving patient prognosis.
View Article and Find Full Text PDFNeurol Sci
December 2024
Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nan-Li-Shi Road, Beijing, 100045, China.
Background: This study investigated RANBP2 mutations in children with acute necrotizing encephalopathy (ANE) and conducted a systematic review of the differences in clinical characteristics between with or without RANBP2 mutations.
Methods: Whole-exome sequencing was performed on 19 pediatric ANE patients at Beijing Children's Hospital affiliated to Capital Medical University between 2017 and 2020. A systematic literature review was also conducted on the clinical characteristics and spectrum analysis of RANBP2 mutations.
Acta Psychiatr Scand
December 2024
Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, The Netherlands.
BMC Med
December 2024
Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Helicobacter pylori infection causes gastritis, peptic ulcers, and gastric cancer. The infection is typically acquired in childhood and persists throughout life. The major impediment to successful therapy is antibiotic resistance.
View Article and Find Full Text PDFBMC Cancer
December 2024
Department of Cancer Epidemiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 45008, China.
Background: It has been proposed that risk model-based strategies could serve as viable alternatives to traditional risk factor-based approaches in lung cancer screening; however, there has been no systematic discussion. In this review, we provide an overview of the benefits, harms, and cost-effectiveness of these two strategies in lung cancer screening application, as well as discussing possible future research directions.
Methods: Following the PRISMA guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, Cochrane libraries, and EMBASE from January 1994 to April 2024.
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