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Management of Splenic Vascular Anomalies: A Review of 17 Pediatric Cases at a Single Institution.
J Pediatr Surg
February 2025
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Surgery, Division of Pediatric Surgery, Texas Children's Hospital, 6701 Fannin Street, Houston, TX 77030, USA. Electronic address:
Background: Splenic Vascular Anomalies (SVA) are rare splenic masses seen in the pediatric population. There is limited information regarding the management and appropriate follow-up for these patients. The aim of this study was to review our experience and create an algorithm to help guide clinical care.
View Article and Find Full Text PDFCorrelation of Genetic Mutation With Outcomes in Children With Hereditary Spherocytosis Undergoing Partial Splenectomy: A Multicentre Study.
J Pediatr Surg
January 2025
Division of General & Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada; Department of Surgery, The University of Toronto, Toronto, ON, Canada.
Purpose: Hereditary Spherocytosis (HS) is a common genetic hematological disorder causing a life-long hemolytic anemia, with sequela of hemolysis. Children with severe HS commonly undergo partial or total splenectomy (PS, TS); PS confers the theoretical advantage of maintaining splenic immune function, but may be associated with regrowth, ongoing hemolysis, and need for completion splenectomy. HS can be caused by 5 different pathogenic gene variants.
View Article and Find Full Text PDFA Case Series and Literature Review on Zanubrutinib Therapy for the Treatment of Relapsed/Refractory Immune Thrombocytopenia.
Cancer Rep (Hoboken)
February 2025
Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Hemostasis and Thrombosis Diagnostic Engineering Research Center of Henan Province, Zhengzhou, China.
Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterised by low platelet count. Treatment discontinuation or heterogeneity in the pathogenesis of ITP heightens the occurrence of relapsed or refractory ITP. Bruton's tyrosine kinase (BTK) has emerged as a promising target for autoimmune disorders.
View Article and Find Full Text PDFSplenic Sclerosing Angiomatoid Nodular Transformation in an 8-Year-Old Child.
J Korean Soc Radiol
January 2025
Sclerosing angiomatoid nodular transformation (SANT) of the spleen is extremely rare in pediatric patients. Here, we report the case of an 8-year-old boy with iron-deficiency anemia and a solitary splenic mass detected using US, CT, and MRI. The patient underwent partial splenectomy, and the final diagnosis was SANT.
View Article and Find Full Text PDFPartial splenectomy for massive malarial splenomegaly: A unique case from an Australian regional centre.
Int J Surg Case Rep
March 2025
The General Surgery Department at the Cairns Hospital, 165 The Esplanade, Cairns, QLD 4870, Australia; The James Cook University, 1/14-88 McGregor Rd, Smithfield, QLD 4878, Australia.
Introduction And Importance: This report describes a rare and remarkable case of partial splenectomy (PS) performed to manage the sequelae of massive malarial splenomegaly. It is likely the first reported case to date.
Case Presentation: A 40-year-old female from Papua New Guinea presented shocked to a remote hospital in the Torres Strait Islands.
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