Background: Patients with sub-acute cerebral venous sinus thrombosis experience (SA.CVST) severe symptoms compared to two other venous sinus-related diseases, including chronic cerebral venous sinus thrombosis (C.CVST) and idiopathic intracranial hypertension (IIH).
Objective: This study aimed to determine whether the different immune reactions in different venous sinuses are related.
Methods: Stagnant blood in the cerebral venous sinuses was extracted by passing a microcatheter and -positive cells were sorted by magnetic beads and subjected to RNA-seq sequencing.
Results: Compared to patients with IIH, 128 genes were significantly down-regulated and 373 genes were significantly up-regulated in the sub-acute CVST samples. The functions of these genes were mainly focused on "immune response", "T cell activation" and "plasma membrane". Gene Set Enrichment Analysis (GSEA) showed T cell survival and activation-related function significantly unregulated in sub-acute CVST. On the other hand, there were 366 genes down-regulated in chronic CVST and 75 genes up-regulated in chronic CVST. In functional annotation, these differently expressed genes were enriched in the "extracellular region", "chemokine-mediated signaling pathway" and "immune response". GSEA analysis confirmed that chemokine-related functions were all up-regulated in sub-acute CVST and monocyte-macrophage adhesion functions were also significantly up-regulated.
Conclusion: This study suggested the -positive created an activated immune response in sub-acute CVST.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599252 | PMC |
http://dx.doi.org/10.3389/fcell.2024.1488005 | DOI Listing |
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