A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Genotype and Biological Age Impact Inter-Omic Associations Related to Bioenergetics. | LitMetric

AI Article Synopsis

  • Apolipoprotein E (ApoE) influences aging, with its ε2 allele linked to longevity and ε4 allele associated with a higher risk of Alzheimer's disease (AD).
  • A study involving 2,229 individuals identified that certain metabolites, specifically diacylglycerols, were elevated in ε2-carriers and showed a trend upward in ε4-carriers compared to ε3-homozygotes, despite their different effects on aging.
  • The findings suggested a complex relationship between ApoE genotypes and biological aging, highlighting the role of bioenergetic pathways and insulin resistance markers in this connection.

Article Abstract

Apolipoprotein E ( ) modifies human aging; specifically, the ε2 and ε4 alleles are among the strongest genetic predictors of longevity and Alzheimer's disease (AD) risk, respectively. However, detailed mechanisms for their influence on aging remain unclear. Herein, we analyzed inter-omic, context-dependent association patterns across genotypes, sex, and health axes in 2,229 community-dwelling individuals to test genotypes for variation in metabolites and metabolite-associations tied to a previously-validated metric of biological aging (BA) based on blood biomarkers. Our analysis, supported by validation in an independent cohort, identified top -associated plasma metabolites as diacylglycerols, which were increased in ε2-carriers and trended higher in ε4-carriers compared to ε3-homozygotes, despite the known opposing aging effects of the allele variants. 'Omics association patterns of ε2-carriers and increased biological age were also counter-intuitively similar, displaying increased associations between insulin resistance markers and energy-generating pathway metabolites. These results provide an atlas of -related 'omic associations and support the involvement of bioenergetic pathways in mediating the impact of on aging.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601402PMC
http://dx.doi.org/10.1101/2024.10.17.618322DOI Listing

Publication Analysis

Top Keywords

biological age
8
association patterns
8
aging
5
genotype biological
4
age impact
4
impact inter-omic
4
inter-omic associations
4
associations bioenergetics
4
bioenergetics apolipoprotein
4
apolipoprotein modifies
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!