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Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from . | LitMetric

Eight monoterpene indole alkaloids (-), including one new picraline-type alkaloid, 2-hydroxyakuammiline () and seven known compounds: akuammigine (), akuammine (), akuammidine (), akuammiline (), akuammiline N-oxide (), akuammiline (), rhazimol (), and alstonine () were isolated from the seeds of . Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds - were moderate. Compound showed significant effects with pXC50 of 6.3. Compounds and showed significant trypanocidal effects with pXC50's of 5.1 and 5.4 respectively.

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http://dx.doi.org/10.1080/14786419.2024.2434710DOI Listing

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