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Identification of a novel immune checkpoint-related gene signature predicts prognosis and immunotherapy in breast cancer and experiment verification.
Sci Rep
December 2024
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Breast cancer (BRCA) is one of the pivotal causes of female death worldwide. And the morbidity and mortality of breast cancer have increased rapidly. Immune checkpoints are important to maintain immune tolerance and are regarded as important therapeutic targets.
View Article and Find Full Text PDFAI-Assisted High-Throughput Tissue Microarray Workflow.
Methods Protoc
November 2024
Institute for Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Immunohistochemical (IHC) studies of formalin-fixed paraffin-embedded (FFPE) samples are a gold standard in oncology for tumor characterization, and the identification of prognostic and predictive markers. However, despite the abundance of archived FFPE samples, their research use is limited due to the labor-intensive nature of IHC on large cohorts. This study aimed to create a high-throughput workflow using modern technologies to facilitate IHC biomarker studies on large patient groups.
View Article and Find Full Text PDFClinical Molecular Testing for Clonal Relatedness of Second Melanoma Tumors.
Arch Pathol Lab Med
December 2024
From the Departments of Pathology, University of Michigan Medical School, Ann Arbor (Plotzke, Manthei, Fullen, Chan, Bresler, Xiao, Andea, Harms).
Context.—: Patients with melanoma can develop second tumors representing either metastases or new primary melanoma. This distinction has profound implications for management.
View Article and Find Full Text PDFThe emerging role of S100A4 and S100A14 proteins in colorectal cancer progression.
Cell Mol Biol (Noisy-le-grand)
November 2024
College of Medicine, University of Duhok, Duhok, Iraq.
Colorectal cancer (CRC) is the third most frequent type of cancer and the second leading cause of cancer-related deaths globally. Despite a thorough understanding of its biology, etiology, and epidemiology, an estimated 1.8 million new cases are diagnosed each year, and 900000 people die as a result of malignancy.
View Article and Find Full Text PDFLong-term survival after local immunotherapy for malignant gliomas: a retrospective study with 20 years follow-up.
BMC Immunol
December 2024
Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Purpose: Immunotherapy is a promising treatment for cancers but should be optimized for malignant gliomas. Because of immune privilege feature of the brain, local administration of immunotherapy may be a promising strategy for malignant glioma treatment. Identification of patients who may benefit from local immunotherapy is essential.
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