Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.
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| http://dx.doi.org/10.1039/d4cc05043f | DOI Listing |
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