Anomaly detection (AD) has emerged as a prominent area of research in hyperspectral imagery (HSI) processing. Traditional algorithms, such as low-rank and sparse matrix decomposition (LRaSMD), often struggle to effectively address challenges related to background interference, anomaly targets, and noise. To overcome these limitations, we propose a novel method that leverages both spatial and spectral features in HSI. Initially, the original HSI is segmented into several subspaces using the k-means method, which reduces redundancy among HSI bands. Subsequently, the fractional Fourier transform (FrFT) is applied within each subspace, enhancing the distinction between background and anomaly target information while simultaneously suppressing noise. To further improve the stability and discriminative power of the HSI, LRaSMD is employed. Finally, the modified Reed-Xiaoli (RX) detector is utilized to identify anomalies within each subspace. The results from these detections are then aggregated to produce a comprehensive final outcome. Experiments conducted on five real HSI data sets yield an average area under the curve (AUC) of 0.9761 with a standard deviation of 0.0156 for the proposed algorithm. These results indicate that our method is highly competitive in the field of anomaly detection.
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http://dx.doi.org/10.1038/s41598-024-80137-3 | DOI Listing |
Pharmaceutics
December 2024
Phase I Clinical Trial Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Background: A broad-spectrum anti-SARS-CoV-2 monoclonal antibody (mAb), SA55, is highly effective against SARS-CoV-2 variants. This trial aimed at demonstrating the safety, tolerability, local drug retention and neutralizing activity, systemic exposure level, and immunogenicity of the SA55 nasal spray in healthy individuals.
Methods: This phase I, dose-escalation clinical trial combined an open-label design with a randomized, controlled, double-blind design.
Pathogens
January 2025
Japan Fisheries Research and Education Agency, Pathology Division, Aquaculture Research Department, Fisheries Technology Institute, Minami-Ise 516-0193, Mie, Japan.
Pinctada birnavirus (PiBV) is the causative agent of summer atrophy in pearl oyster ( (Gould)). The disease, which induces mass mortality in juveniles less than 1 year old and abnormalities in adults, was first reported in Japan in 2019. Research on the disease has been hindered by the lack of cell lines capable of propagating PiBV.
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January 2025
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK.
The domestic dog () is a competent host for () infection but no ante mortem diagnostic tests have been fully validated for this species. The aim of this study was to compare the performance of ante mortem diagnostic tests across samples collected from dogs considered to be at a high or low risk of sub-clinical infection. We previously tested a total of 164 dogs at a high risk of infection and here test 42 dogs at a low risk of infection and 77 presumed uninfected dogs with a combination of cell-based and/or serological diagnostic assays previously described for use in non-canid species.
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January 2025
Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia.
Introduction: Gait analysis is a vital tool in the assessment of human movement and has been widely used in clinical settings to identify potential abnormalities in individuals. However, there is a lack of consensus on the normative values for gait metrics in large populations. The primary objective of this study is to establish a normative database of spatiotemporal gait metrics across various age groups, contributing to a broader understanding of human gait dynamics.
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January 2025
Department of Innovation Engineering, University of Salento, 73100 Lecce, Italy.
In recent years, the growing number of vehicles on the road have exacerbated issues related to safety and traffic congestion. However, the advent of the Internet of Vehicles (IoV) holds the potential to transform mobility, enhance traffic management and safety, and create smarter, more interconnected road networks. This paper addresses key road safety concerns, focusing on driver condition detection, vehicle monitoring, and traffic and road management.
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