[The prognostic value of BAP1 protein loss in patients with malignant mesothelioma].

To explore the prognostic value of BRCA1-associated protein 1 (BAP1) expression loss in patients with malignant mesothelioma (MM) . A total of 82 MM patients from January 1998 to December 2017 in Zhejiang Province were selected to detect the expression of BAP1 protein by immunohistochemical analysis. Kaplan-Meier method was used to draw the survival curve, and multivariate Cox proportional risk model was used to analyze the factors affecting the survival rate. Among 82 MM patients, 61 (74.4%) were female, aged (57±11) years. BAP1 protein expression was deficient in 39 patients (47.6%). The survival rate was correlated with the loss of BAP1 protein expression and age (χ(2)=5.27, 5.66, =0.022, 0.017). Subgroup analysis showed that loss of BAP1 protein expression was associated with better prognosis in MM patients <57 years of age, female, pleural MM, epithelial MM, and treated with drugs or surgery (<0.05). Multivariate model results showed that positive expression of BAP1 protein (=3.75, 95%: 2.23-6.30, <0.001) and age ≥57 years (=1.66, 95% : 1.01-2.72, =0.049) were risk factors for survival in patients with MM. Loss of BAP1 protein expression may be an independent prognostic factor in patients with MM, which is associated with longer survival.