Background: The pRESET stent retriever is a self-expanding nitinol stent designed for mechanical thrombectomy in cases of large vessel occlusion during acute ischemic stroke. This systematic review and meta-analysis synthesize the available evidence on the safety and efficacy of the pRESET device.
Methods: This is a systematic review and meta-analysis study conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The electronic databases of PubMed, Embase, WoS, and Scopus were systematically reviewed from inception to 8 July 2024.
Results: A total of eight studies involving 1163 patients were included. The pooled mortality rate was 18% with a 95% CI of [12%, 25%]. The rates of any hemorrhagic complication, parenchymal hemorrhage, and subarachnoid hemorrhage were 22% with a 95% CI of [12%, 36%], 7% with a 95% CI of [4%, 13%], and 10% with a 95% CI of [5%, 17%], respectively. The rate of favorable functional outcome (modified Rankin Scale 0-2) at 90 days was 43% with a 95% CI of [34%, 52%]. Successful recanalization rates were 60% with a 95% CI of [52%, 67%] after the first pass and 90% with a 95% CI of [83%, 95%] after the final pass. Rescue devices were used in 13% with a 95% CI of [7%, 24%] of cases.
Conclusions: The pRESET stent retriever demonstrates high recanalization rates and reasonable safety outcomes in patients undergoing mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion. Further randomized trials directly comparing pRESET to other stent retrievers are warranted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603420 | PMC |
| http://dx.doi.org/10.1177/19714009241303083 | DOI Listing |
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The safety and efficacy of pRESET stent retriever for treatment of thrombo-embolic stroke; a systematic review and meta-analysis.
Neuroradiol J
November 2024
Student Research Committee, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
Background: The pRESET stent retriever is a self-expanding nitinol stent designed for mechanical thrombectomy in cases of large vessel occlusion during acute ischemic stroke. This systematic review and meta-analysis synthesize the available evidence on the safety and efficacy of the pRESET device.
Methods: This is a systematic review and meta-analysis study conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Inadvertent Detachment of Stent Retrievers: Report of 2 Cases.
Neurointervention
November 2024
Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Mechanical thrombectomy using a stent retriever is a widely-used technique for recanalizing occluded cerebral arteries in acute ischemic stroke. Although rare, inadvertent stent detachment has primarily been reported with earlier stent retriever designs. We present 2 cases of inadvertent stent detachment with the pRESET stent.
View Article and Find Full Text PDFpRESET thrombectomy device outcomes in patients with acute ischemic stroke: A systematic review and meta-analysis.
Interv Neuroradiol
September 2024
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- The study evaluated the efficacy and safety of pRESET stent-retriever systems for treating large vessel occlusion acute ischemic stroke through a systematic review and meta-analysis of relevant studies until March 2024.
- A total of 1140 participants were analyzed, revealing that pRESET systems achieved a notable first-passing effect rate of 53.4% and a high rate of successful thrombolysis (90.41%).
- The findings suggest that the pRESET device has a comparable safety and efficacy profile to existing mechanical thrombectomy devices, with a 90-day mortality rate of 15.1% and a post-intervention hemorrhage rate of 28.6%.
Is Stent Retraction to ReLieve Arterial Cerebral VaSospasm Caused by SAH (Stent-ReLACSS) Using PRELAX the Long-awaited Solution for Treatment of Posthemorrhagic Cerebral Vasospasm? : Treatment of Posthemorrhagic Cerebral Vasospasm with PRESET and PRELAX: Technical Aspects, Efficacy, and Safety Margins in a Case Series.
Clin Neuroradiol
September 2024
Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Stuttgart, Germany.
Purpose: Recent observational studies have indicated the efficacy of stent retriever devices for the treatment of posthemorrhagic cerebral vasospasm (CVS), both by deployment and on-site withdrawal into the microcatheter (stent angioplasty, SA) and deployment followed by retraction through the target vessel similar to thrombectomy (Stent Retraction to reLieve Arterial Cerebral vaSospasm caused by SAH, Stent-ReLACSS). This article reports the findings with each application of pRESET and pRELAX in the treatment of CVS.
Methods: We retrospectively enrolled 25 patients with severe CVS following aneurysmal subarachnoid hemorrhage.
Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation.
Neuroradiology
April 2024
Department of Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of the pRESET LITE stent retriever for treating medium vessel occlusions in acute ischemic stroke patients.
- A retrospective analysis included 227 patients from 37 institutions, distinguishing between proximal and distal occlusions, revealing successful reperfusion rates of 85% and 97%, respectively.
- Despite a 7% complication rate and a significant percentage of patients experiencing hemorrhagic transformations, the procedure showed a favorable outcome in 58% of cases after three months.
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