AI Article Synopsis
- The study aims to analyze medication adherence and persistence in heart failure patients, focusing on methods of measurement and their impact on health outcomes.
- A systematic search of various databases will be conducted to include observational studies, with plans for narrative synthesis and a meta-analysis to evaluate how adherence affects clinical results like hospitalizations and mortality rates.
- Results will guide improvements in research practices and patient care by identifying effective adherence thresholds and addressing current measurement limitations.
Article Abstract
Objective: To study medication adherence and persistence among heart failure patients, assess the methods utilized for estimating medication adherence, and identify optimal adherence thresholds and their impact on clinical outcomes.
Methods: A systematic search will be conducted in PubMed, Embase, CINAHL, Web of Science, and Scopus databases. Observational studies assessing medication adherence or persistence among heart failure patients via electronic healthcare databases will be included. A narrative synthesis will describe medication adherence and persistence reported and methods used to measure it. A meta-analysis will be attempted to evaluate the impact of secondary medication adherence (multiple and by drug class) on clinical outcomes, including hospitalization, emergency visits, and mortality. The I statistic will be employed to study heterogeneity and the GRADE framework to evaluate evidence certainty. This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines and is registered with the Prospective Register of Ongoing Systematic Reviews (PROSPERO) CRD42024509542.
Discussion: This study aims to evaluate medication adherence and persistence in heart failure management through electronic health databases, intending to explore widely used measurement methods and their limitations, and to identify adherence thresholds associated with improved clinical outcomes. By examining these aspects, we anticipate proposing enhancements for future research and establishing desired adherence goals. This approach highlights the expected significance of our findings in advancing patient care and research methodologies.
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| http://dx.doi.org/10.1016/j.farma.2024.10.013 | DOI Listing |
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