Head shape changes following spring-cranioplasty for craniosynostosis (CS) can be difficult to predict. While previous research has indicated a connection between surgical outcomes and calvarial bone microstructure ex-vivo, there exists a demand for identifying imaging biomarkers that can be translated into clinical settings and assist in predicting these outcomes. In this study, ten parietal (8 males, age 157 ± 26 days) and two occipital samples (males, age 1066 and 1162 days) were collected from CS patients who underwent spring cranioplasty procedures. Samples' microstructure were examined using clinical imaging modalities (dental CBCT, C-arm CT) and micro-CT. Cranial index (CI) was measured to evaluate patients' head shape before and after surgery, with an investigation into their relationship with morphometric measurements. Bone cross-sectional thickness (CsTh) showed significant correlation to CI increase post-SAC for C-arm CT (ρ = -0.857, p = 0.014) and 8.9 μm micro-CT (ρ = -0.857, p = 0.014). In addition, bone volume (BV) was correlated to CI increase for CBCT (ρ = -0.643, p = 0.013), 50 μm micro-CT (ρ = -0.857, p < 0.001) and 90 μm micro-CT (ρ = -0.679, p = 0.008). High correlation with micro-CT resampled to match respective voxel sizes was demonstrated for both CBCT and C-arm CT measurements of CsTh and BV (ρ ≥ 0.860, p < 0.001). This preliminary study demonstrates the potential of clinical CT devices to aid in pre-surgical decision making in CS.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcms.2024.11.014DOI Listing

Publication Analysis

Top Keywords

head shape
12
bone microstructure
8
shape changes
8
males age
8
ρ = -0857 p = 0014
8
micro-ct ρ = -0857
8
cone beam
4
beam assessment
4
bone
4
assessment bone
4

Similar Publications

Background: Wireless capsule endoscopy (WCE) has become an important noninvasive and portable tool for diagnosing digestive tract diseases and has been propelled by advancements in medical imaging technology. However, the complexity of the digestive tract structure, and the diversity of lesion types, results in different sites and types of lesions distinctly appearing in the images, posing a challenge for the accurate identification of digestive tract diseases.

Aim: To propose a deep learning-based lesion detection model to automatically identify and accurately label digestive tract lesions, thereby improving the diagnostic efficiency of doctors, and creating significant clinical application value.

View Article and Find Full Text PDF

A Rare Presentation of Synchronous Thyroglossal Cyst and Branchial Cyst in an Adult Male Patient.

Cureus

November 2024

Otolaryngology - Head and Neck Surgery, Shri B.M. Patil Medical College, Hospital and Research Centre, Vijayapura, IND.

The most common congenital cervical masses are thyroglossal cysts followed by branchial cleft anomalies. However, their synchronous presentation is uncommon. A man in his early thirties visited our ear, nose, and throat (ENT) outpatient department (OPD) with complaints of a three-month history of right-side neck swelling.

View Article and Find Full Text PDF

Comparison of HDR-brachytherapy and tomotherapy for the treatment of non-melanoma skin cancers of the head and neck.

Radiother Oncol

December 2024

Medical Physics Unit, IRCCS, Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Italy. Electronic address:

Purpose: This study aims to investigate and compare High Dose Rate Brachytherapy (HDR-BT) with Helical Tomotherapy (HT) treatment plans. The focus is on small target volumes near radiation-sensitive organs in the ocular region, to evaluate the advantages of these techniques in treating skin cancer.

Methods: This retrospective observational analysis included patients who underwent skin cancer HDR-BT Freiburg flap treatment between 2019 and 2023.

View Article and Find Full Text PDF

The limited and inconsistent adoption and regulation of nurse-led clinics (NLCs) and "See & Treat" (S&T) services in Italy needs to be explored considering their value towards patients' outcomes acknowledged in the literature. This study aims to explore the phenomenon of hidden nursing activities (HNAs) in these settings, hypothesizing that features and activities performed in these settings are heterogeneous across the country and widely underreported or attributed to other professionals than nurses. HNAs are hypothesized to be associated with a poor work environment climate and nurses' low job satisfaction.

View Article and Find Full Text PDF

3D photogrammetry is a cost-effective, non-invasive imaging modality that does not require the use of ionizing radiation or sedation. Therefore, it is specifically valuable in pediatrics and is used to support the diagnosis and longitudinal study of craniofacial developmental pathologies such as craniosynostosis - the premature fusion of one or more cranial sutures resulting in local cranial growth restrictions and cranial malformations. Analysis of 3D photogrammetry requires the identification of craniofacial landmarks to segment the head surface and compute metrics to quantify anomalies.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!