AI Article Synopsis

  • * A needle biopsy of an enlarged left axillary lymph node revealed a different type of diffuse large B-cell lymphoma, indicating a complex lymphoma situation rather than a simple case of fluid overload.
  • * Both lymphomas displayed different levels of CD10 expression but were found to be clonally related with a shared MYD88 L265P mutation, demonstrating a conflict between traditional criteria for classification and genetic analysis results.

Article Abstract

A 79-year-old Japanese woman presented with exertional dyspnea. She had cardiac tamponade and urgent pericardial drainage was performed. Pathological findings from the pericardial fluid revealed non-germinal center B-cell (non-GCB) pericardial large B-cell lymphoma (CD10, BCL6, and MUM1). Although a diagnosis of fluid overload-associated large B-cell lymphoma was considered, GCB nodal diffuse large B-cell lymphoma (CD10, BCL6, and MUM1) was discovered through needle biopsy of the enlarged left axillary lymph node. Despite the two lymphomas exhibiting different expression levels of CD10, polymerase chain reaction assessing IgH gene rearrangement suggested a clonal relationship between them. Additionally, MYD88 L265P mutation was confirmed using Sanger sequencing in both samples, suggesting the MCD type. Our case highlights a discrepancy between the Hans' criteria and the gene expression profile-based cell of origin.

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Source
http://dx.doi.org/10.3960/jslrt.24050DOI Listing

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