AI Article Synopsis
- - The study investigated the cognitive profiles of older people with HIV (OPWH) undergoing combined antiretroviral therapy, focusing on how age interacts with HIV-related cognitive disorders.
- - Researchers conducted a cross-sectional analysis of 330 OPWH aged 50 and older, using neuropsychological tests to evaluate cognitive functions and identify clusters of cognitive impairment.
- - Results showed three distinct cognitive clusters: one with significant memory impairments, another with language and abstraction issues, and a third with no specific domain impairments, suggesting variations based on both HIV-related and other individual factors.
Article Abstract
Background: Age and HIV are synergistic risk factors for conditions such as HIV-associated neurocognitive disorders (HAND). Yet, it is unclear whether older persons with HIV (OPWH) display different cognitive profiles for HAND.
Objective: To describe the cognitive patterns of OPWH treated with combined antiretroviral therapy (cART).
Methods: Cross-sectional study that included 330 participants with HIV, aged 50 years or older, cared for at a tertiary care hospital in Mexico City. A short neuropsychological test battery was used to assess a wide spectrum of cognitive functions. The optimal number of cognitive clusters was determined by the silhouette method and a minimization of the Bayesian information criterion.
Results: Participants' mean age was 58.8 years (standard deviation = 6.6), and 12.1% were women. A 3-cluster solution yielded stable Jaccard coefficients (p > 0.70). Cluster 1 showed more significant impairment in visual and verbal memory domains, whereas participants in cluster 3 showed significant impairment in language, and abstraction. Cluster 2 showed no predominance of any domain for alterations.
Conclusions: There are different cognitive profiles among OAWH with HAND. These differences may be due to individual patterns of HIV-related and non-HIV-related factors.
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| http://dx.doi.org/10.24875/GMM.23000423 | DOI Listing |
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