Ru(II)-catalyzed, carboxylic acid-assisted oxidative annulation of -aryl azoles with alkynes via double C-H activation to produce highly functionalized π-extended imidazo[1,2-]quinolines is reported. The reaction features a broad substrate generality and tolerates various biologically relevant scaffolds. Interestingly, annulated products showed strong fluorescence properties and an AgIE effect and exhibited a selective fluorescent response toward the Cu ion. Further photocatalytic properties of the product are demonstrated in the photochemical coupling of azoles and arenes.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.4c03522DOI Listing

Publication Analysis

Top Keywords

π-extended imidazo[12-]quinolines
8
carboxylic acid-assisted
8
c-h activation
8
synthesis π-extended
4
imidazo[12-]quinolines carboxylic
4
acid-assisted ruii-catalyzed
4
ruii-catalyzed dual
4
dual c-h
4
activation alkyne
4
alkyne annulation
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!