Molecular motors generate force to individually power molecular machines or collectively drive macroscopic actuators. The force output of molecular and macroscale motors appears to be constrained by the same scaling law relating motor force and mass. Here, potential origins of these universal performance characteristics are discussed and the implications examined.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/scirobotics.adl0842 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Zebrafish as a model to understand extraocular motor neuron diversity.
Curr Opin Neurobiol
December 2024
Departments of Otolaryngology, Neuroscience, and the Neuroscience Institute, NYU Grossman School of Medicine, USA. Electronic address:
Motor neurons have highly diverse anatomical, functional and molecular features, and differ significantly in their susceptibility in disease. Extraocular motor neurons, residing in the oculomotor, trochlear and abducens cranial nuclei (nIII, nIV and nVI), control eye movements. Recent work has begun to clarify the developmental mechanisms by which functional diversity among extraocular motor neurons arises.
View Article and Find Full Text PDFDisrupted callosal connectivity underlies long-lasting sensory-motor deficits in an NMDAreceptor antibody encephalitis mouse model.
J Clin Invest
December 2024
Department of Neurology, UCSF, San Francisco, United States of America.
NMDA receptor mediated autoimmune encephalitis (NMDAR-AE) frequently results in persistent sensory-motor deficits, especially in children, yet the underlying mechanisms remain unclear. This study investigated the long- term effects of exposure to a patient-derived GluN1-specific monoclonal antibody (mAb) during a critical developmental period (from postnatal day 3 to day 12) in mice. We observed long-lasting sensory-motor deficits characteristic of NMDAR-AE, along with permanent changes in callosal axons within the primary somatosensory cortex (S1) in adulthood, including increased terminal branch complexity.
View Article and Find Full Text PDFNucleic Acid Packaging in Viruses.
Subcell Biochem
December 2024
Department of Macromolecular Structure, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Viruses shield their genetic information by enclosing the viral nucleic acid inside a protein shell (capsid), in a process known as genome packaging. Viruses follow essentially two main strategies to package their genome: Either they co-assemble their genetic material together with the capsid protein or an empty shell (procapsid) is first assembled and then the genome is pumped inside the capsid by a molecular motor that uses the energy released by ATP hydrolysis. During packaging the viral nucleic acid is highly condensed through a meticulous arrangement in concentric layers inside the capsid.
View Article and Find Full Text PDFOptical Tweezers to Study Viruses.
Subcell Biochem
December 2024
Centro de Tecnologías Físicas, Universitat Politècnica de València, Valencia, Spain.
A virus is a complex molecular machine that propagates by channeling its genetic information from cell to cell. Unlike macroscopic engines, it operates in a nanoscopic world under continuous thermal agitation. Viruses have developed efficient passive and active strategies to pack and release nucleic acids.
View Article and Find Full Text PDFRBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation.
Commun Biol
December 2024
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Brain-derived neurotrophic factor (BDNF) plays important roles in brain development and neural function. Constitutive knockout of the splicing regulator RBM4 reduces BDNF expression in the developing brain and causes cerebellar hypoplasia, an autism-like feature. Here, we show that Rbm4 knockout induced intron 6 retention of Hsf1, leading to downregulation of HSF1 protein and its downstream target BDNF.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!