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http://dx.doi.org/10.1001/jamaoncol.2024.5519 | DOI Listing |
FEMS Yeast Res
March 2025
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Komagataella phaffii has gained recognition as a versatile platform for recombinant protein production, with applications covering biopharmaceuticals, industrial enzymes, food additives, etc. Its advantages include high-level protein expression, moderate post-translational modifications, high-density cultivation, and cost-effective methanol utilization. Nevertheless, it still faces challenges for the improvement of production efficiency and extension of applicability.
View Article and Find Full Text PDFJ Am Coll Cardiol
March 2025
National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom.
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed chronic disease associated with progressive heart failure that results in impaired quality of life, repeated hospitalizations, and premature death. Acoramidis is a selective, oral transthyretin stabilizer recently approved by the U.S.
View Article and Find Full Text PDFJ Genet Eng Biotechnol
March 2025
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address:
Background: Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research.
View Article and Find Full Text PDFEnviron Health Prev Med
March 2025
Department of Biostatistics, School of Public Health, Harbin Medical University.
Background: There is growing evidence that the occurrence and severity of respiratory diseases in children are related to the concentration of air pollutants. Nonetheless, evidence regarding the association between short-term exposure to air pollution and outpatient visits for respiratory diseases in children remains limited. Outpatients cover a wide range of disease severity, including both severe and mild cases, some of which may need to be transferred to inpatient treatment.
View Article and Find Full Text PDFBMJ Open
March 2025
Department of Primary Care Federative, Nantes Universite, Nantes, France.
Objective: To assess whether patient experience is better for patients followed in a primary care team (PCT) than for patients with traditional follow-up in usual care.
Design: A cross-sectional survey based on a self-administered questionnaire.
Setting: Pays de la Loire geographical area (located on the French west coast).
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