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| http://dx.doi.org/10.1148/ryai.240660 | DOI Listing |
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Recent progress in CRISPR-Cas-system for neurological disorders.
Prog Mol Biol Transl Sci
January 2025
Genetics & Developmental Biology Laboratory, Department of Biotechnology & Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat, India. Electronic address:
Different neurological diseases including, Parkinson's, Alzheimer's, and Huntington's diseases extant momentous global disease burdens, affecting millions of lives for imposing a heavy disease burden on the healthcare systems. Despite various treatment strategies aimed at alleviating symptoms, treatments remain elusive and ineffective due to the disease's complexity. However, recent advancements in gene therapy via the CRISPR-Cas system offer ground-breaking and targeted treatment options.
View Article and Find Full Text PDFMapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom.
Sci Rep
January 2025
Radiation Biophysics and Radiobiology Laboratory, Physics Department, University of Pavia, Pavia, Italy.
We present new developments for an ab-initio model of the neutron relative biological effectiveness (RBE) in inducing specific classes of DNA damage. RBE is evaluated as a function of the incident neutron energy and of the depth inside a human-sized reference spherical phantom. The adopted mechanistic approach traces neutron RBE back to its origin, i.
View Article and Find Full Text PDFShear-Mediated Stabilization of Spin Spiral Order in Multiferroic NiI.
Adv Mater
January 2025
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Type-II multiferroicity from non-collinear spin order is recently explored in the van der Waals material NiI. Despite the importance for improper ferroelectricity, the microscopic mechanism of the helimagnetic order remains poorly understood. Here, the magneto-structural phases of NiI are investigated using resonant magnetic X-ray scattering (RXS) and X-ray diffraction.
View Article and Find Full Text PDFStudy on the crack propagation morphology and initiation law of coal rock under the action of underwater electric pulse.
Sci Rep
January 2025
School of Resources and Civil Engineering, Northeastern University, Shenyang, 110819, China.
Based on the symmetric initiation mechanism of double-wing cracks in coal rock mass induced by high-pressure electro-recoil water pressure, fracturing experiments have been performed on coal rock mass under different water pressures and discharge conditions using high-voltage electric pulse hydraulic fracturing devices. Combined with CT scans, the crack spatial distribution inside the post-break coal rock mass was analyzed and found that the edge of the water injection hole is prone to produce double-wing cracks along the drilling hole diameter. ABAQUS is used to verify the physical test and extend the test conditions, the geometric parameter change, morphological expansion rule and crack initiation mechanism of double-wing crack in coal rock mass under different discharge conditions and ground stress conditions are studied.
View Article and Find Full Text PDFTowards a comprehensive definition of the human fascial system.
J Anat
January 2025
Department of Pathology, New York University Grossman School of Medicine, New York, New York, USA.
The absence of a clear consensus on the definition and significance of fascia and the indiscriminate use of the term throughout the clinical and scientific literature has led to skepticism regarding its importance in the human body. To address this challenge, we propose that: (1) fasciae, and the fascial interstitia within them, constitute an anatomical system, defined as a layered body-wide multiscale network of connective tissue that allows tensional loading and shearing mobility along its interfaces; (2) the fascial system comprises four anatomical organs: the superficial fascia, musculoskeletal (deep) fascia, visceral fascia, and neural fascia; (3) these organs are further composed of anatomical structures, some of which are eponymous; (4) all these fascial organs and their structural components contain variable combinations and arrangements of the four classically defined tissues: epithelial, connective, muscle, and neural; (5) the overarching functions of the fascial system arise from the contrasting biomechanical properties of the two basic types of layers distributed throughout the system: one predominantly collagenous and relatively stiff, the other rich in hyaluronic acid and viscous, allowing for the free flow of fluid; (6) the topographical organization of these layers in different locations is related to local variations in function (e.g.
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