AI Article Synopsis
- Malignant glioma, a deadly brain cancer, creates an immunosuppressive environment that limits the effectiveness of treatments targeting the immune system.
- Researchers used single-cell RNA sequencing to identify glioma cells expressing CD83, a marker linked to mature immune cells, and studied its effects on tumor growth and immune response in mice and human samples.
- Findings indicate that CD83+ tumor cells may promote anti-tumor activity by enhancing T cell responses and increasing inflammatory signals, suggesting that CD83 could be a potential target for improving immunotherapy in glioma patients.
Article Abstract
Immunosuppression in malignant glioma remains a barrier to therapeutic development. CD83 overexpression in human and mouse glioma increases survival. CD83+ tumor cells promote signatures related to cytotoxic T cells, enhanced activation of CD8+ T cells, and increased proinflammatory cytokines. These findings suggest that tumor-expressed CD83 could mediate tumor-immune communications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683667 | PMC |
| http://dx.doi.org/10.1158/2767-9764.CRC-24-0281 | DOI Listing |
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