Severity: Warning
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Filename: drivers/Session_files_driver.php
Line Number: 177
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File: /var/www/html/index.php
Line: 316
Function: require_once
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Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
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File: /var/www/html/index.php
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Function: require_once
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Message: Undefined array key "choices"
Filename: controllers/Detail.php
Line Number: 249
Backtrace:
File: /var/www/html/application/controllers/Detail.php
Line: 249
Function: _error_handler
File: /var/www/html/index.php
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Function: require_once
Severity: Warning
Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
Line Number: 249
Backtrace:
File: /var/www/html/application/controllers/Detail.php
Line: 249
Function: _error_handler
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
Line Number: 249
Backtrace:
File: /var/www/html/application/controllers/Detail.php
Line: 249
Function: _error_handler
File: /var/www/html/index.php
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Function: require_once
Severity: Warning
Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
Line Number: 249
Backtrace:
File: /var/www/html/application/controllers/Detail.php
Line: 249
Function: _error_handler
File: /var/www/html/index.php
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Function: require_once
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Message: strpos(): Passing null to parameter #1 ($haystack) of type string is deprecated
Filename: models/Detail_model.php
Line Number: 71
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File: /var/www/html/application/models/Detail_model.php
Line: 71
Function: strpos
File: /var/www/html/application/controllers/Detail.php
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Function: insertAPISummary
File: /var/www/html/index.php
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Function: require_once
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Message: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated
Filename: helpers/my_audit_helper.php
Line Number: 8919
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File: /var/www/html/application/helpers/my_audit_helper.php
Line: 8919
Function: str_replace
File: /var/www/html/application/controllers/Detail.php
Line: 255
Function: formatAIDetailSummary
File: /var/www/html/index.php
Line: 316
Function: require_once
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Message: Undefined array key "choices"
Filename: controllers/Detail.php
Line Number: 256
Backtrace:
File: /var/www/html/application/controllers/Detail.php
Line: 256
Function: _error_handler
File: /var/www/html/index.php
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Function: require_once
Severity: Warning
Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
Line Number: 256
Backtrace:
File: /var/www/html/application/controllers/Detail.php
Line: 256
Function: _error_handler
File: /var/www/html/index.php
Line: 316
Function: require_once
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Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
Line Number: 256
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File: /var/www/html/application/controllers/Detail.php
Line: 256
Function: _error_handler
File: /var/www/html/index.php
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Function: require_once
Severity: Warning
Message: Undefined array key "usage"
Filename: controllers/Detail.php
Line Number: 257
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File: /var/www/html/application/controllers/Detail.php
Line: 257
Function: _error_handler
File: /var/www/html/index.php
Line: 316
Function: require_once
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Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
Line Number: 257
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File: /var/www/html/application/controllers/Detail.php
Line: 257
Function: _error_handler
File: /var/www/html/index.php
Line: 316
Function: require_once
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Message: Undefined array key "usage"
Filename: controllers/Detail.php
Line Number: 258
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Function: _error_handler
File: /var/www/html/index.php
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Function: require_once
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Function: require_once
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Message: Undefined array key "usage"
Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Function: _error_handler
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Function: require_once
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Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
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File: /var/www/html/application/helpers/my_audit_helper.php
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Function: file_get_contents
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Function: simplexml_load_file_from_url
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Function: GetPubMedArticleOutput_2016
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Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
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Function: pubMedGetRelatedKeyword
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Function: require_once
Nanocomposites (NCs) have attractive potential applications in gas-sensing, energy, photocatalysis, and biomedicine. In the present work, the fabrication of CuO/ZrO/TiO/RGO nanocomposites (NCs) was done a simple chemical route. Our aim in this work was to synthesis and investigate the selective anticancer activity of TiO NPs by supporting CuO, ZrO, and RGO toward cancer and normal cells. Different analytical techniques, such as X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM) with energy dispersive X-ray (EDX), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, Fourier transform infrared (FTIR) spectroscopy, photoluminescence (PL) spectroscopy, and dynamic light scattering (DLS), were carefully applied to characterize the physicochemical properties of the produced samples. XRD results showed that the phase and crystal structure of TiO NPs were enhanced after adding CuO, ZrO, and RGO. TEM and SEM images showed that CuO/ZrO/TiO/RGO NCs were similarly distributed on RGO sheets with high crystallinity, excellent quality of lattice fringes, and lower agglomeration compared with pure TiO NPs. EDX and XPS analysis confirmed the presence of elements Cu, Zr, Ti, O, and C in the obtained CuO/ZrO/TiO/RGO NCs. Raman and FTIR spectra verified the presence of functional groups and crystal structures in the produced samples. PL data showed that the optical properties of TiO improved after adding CuO, ZrO, and RGO sheets owing to the reduction in the recombination rate between the electron-hole pair. DLS analysis showed that the prepared CuO/ZrO/TiO/RGO NCs had excellent colloidal stability and good distribution in the suspension of the media culture. Anticancer results for CuO/ZrO/TiO/RGO NCs exhibited about 2-fold higher toxicity for 24 h and 4-fold for 48 h against breast cancer (MCF-7) cells than pure TiO NPs, while their biocompatibility was excellent against HUVEC normal cells. Additionally, the IC values of CuO/ZrO/TiO/RGO NCs were 44.19 ± 1.2 μg mL and 24.52 ± 0.8 μg mL for 24 h and 48 h, respectively. These results indicate that adding CuO, ZrO, and RGO plays a crucial role in enhancing the anticancer property of TiO NPs. This study suggests that CuO/ZrO/TiO/RGO NCs could be applied in cancer therapy applications in models.
Download full-text PDF |
Source |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588041 | PMC |
http://dx.doi.org/10.1039/d4ra07039a | DOI Listing |
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