The role of osteocrin in memory formation during early learning, as revealed by visual imprinting in chicks.

Osteocrin (OSTN) is structurally associated with natriuretic peptides. Its expression in the brain, which has only been recognized in anthropoid primates, is induced by sensory stimuli and regulates the activity-dependent dendritic growth of neurons. However, details on the signaling mechanisms of OSTN and its function in plastic changes during learning and memory have yet to be elucidated. We found that OSTN was expressed in the cortical region of the chicken brain. The injection of chicken OSTN (chOSTN) after imprinting training prolonged the memory retention for the imprinting stimulus. Conversely, a reduction in the OSTN receptor chNPR3 inhibited memory retention. The memory retention was positively correlated with a high level of chOSTN and fewer neurites in the cortical region. In conclusion, OSTN-NPR3 signaling promoted memory consolidation and/or retention by regulating neurite branching during childhood.