This study aimed to elucidate the risk of developing breast cancer (BC) by reproductive and hormonal profiles to suggest risk-adapted starting screening ages and to investigate risks after negative mammography results to inform screening intervals in the Korean setting. Participants who performed health examinations between 2002 and 2023 at the National Cancer Center were analyzed. Risk-adapted starting age of screening was defined as the age at which women with various reproductive and hormonal profiles obtained a 10-year cumulative risk level similar to women aged 40 years in the general population. The Cox progression model was used to assess BC risk according to the reproductive and hormonal score and time since the last negative mammography. Of the 24,597 women enrolled in this study, 606 had BC (median follow-up 13.2 years, IQR = 9.5-16.5 years). The 10-year cumulative risk of BC at age 40 years in general women was estimated at 2.35%. Women with different reproductive and hormonal profiles reached this risk level 8.55 years earlier to 4.61 years later. We found that women with various reproductive and hormonal profiles had similar incident cases in both low- and high-score groups beyond 5 years after a negative finding from mammography (p > .05), compared to those screened within 0 to <2 years after negative screening results. This study identifies possible risk-based starting ages for BC screening based on reproductive and hormonal factors. Our findings suggest that extending the current biennial screening interval beyond 5 years may still detect a comparable number of cases.
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http://dx.doi.org/10.1002/ijc.35265 | DOI Listing |
Sci Rep
December 2024
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
No study has examined the association between dietary insulin load (DIL) and insulin index (DII) with developing gestational diabetes mellitus (GDM) during pregnancy. This study aimed to investigate the association between DIL and DII and risk of GDM in a group of pregnant women in Iran. In this prospective cohort study, 812 pregnant in their first trimester were recruited and followed.
View Article and Find Full Text PDFOpen Vet J
November 2024
Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background: Senility influences fertility in women and companion animals, especially horses.
Aim: This study aimed to investigate the effect of aging in horses on the daily changes in the dominant follicle (DF) dynamics and hemodynamics, antimüllerian hormone (AMH), enzymes, antioxidants, and ovarian hormones during the estrous cycle.
Methods: Ovaries of old mares ( = 5, age >20 years) and young native mares ( = 6, age <10 years) were scanned during 6 different estrous cycles from March 2022 to August 2023 with Doppler ultrasound.
BMC Womens Health
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Purpose: Previous studies have suggested a link between serum progesterone levels on the day of the HCG trigger in IVF cycles and oocyte and embryo quality. This study aims to explore this relationship more thoroughly.
Methods: This study included 496 infertility patients at Moloud Infertility Treatment Center, Zahedan, Iran.
BMC Pregnancy Childbirth
December 2024
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, People's Republic of China.
Background: Ectopic pregnancy (EP) accounts for approximately 2% of all pregnancies, with tubal ectopic pregnancies (TEPs) being the most common type. Methotrexate (MTX) is a noninvasive and effective medical management option for TEP, but failure rates range from 10 to 36%, posing challenges in clinical practice. Identifying risk factors for MTX treatment failure is crucial to improve patient outcomes and guide clinical decision-making.
View Article and Find Full Text PDFBMC Med Imaging
December 2024
Department of Radiology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang, 325000, China.
Objective: This study investigates the MRI characteristics of primary and metastatic adult granulosa cell tumor with normal estrogen levels (AGCT-NEL) to enhance clinical understanding and diagnostic accuracy of this disease.
Methods: We collected clinical data from 10 patients with AGCT-NEL, confirmed by pathology, treated at our hospital from January 2016 to January 2024. We retrospectively analyzed the MRI features of primary and metastatic lesions from aspects such as shape, edge characteristics, MRI signal, and enhancement features.
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