Endothermic animals expend significant energy to maintain high body temperatures, which offers adaptability to varying environmental conditions. However, this high metabolic rate requires increased food intake. In conditions of low environmental temperature and scarce food resources, some endothermic animals enter a hypometabolic state known as torpor to conserve energy. Torpor involves a marked reduction in body temperature, heart rate, respiratory rate, and locomotor activity, enabling energy conservation. Despite their biological significance and potential medical applications, the neuronal mechanisms regulating torpor still need to be fully understood. Recent studies have focused on fasting-induced daily torpor in mice due to their suitability for advanced neuroscientific techniques. In this review, we highlight recent advances that extend our understanding of neuronal mechanisms regulating torpor. We also discuss unresolved issues in this research field and future directions.
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http://dx.doi.org/10.1002/bies.202400190 | DOI Listing |
Proc Natl Acad Sci U S A
December 2024
State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Fever confers significant survival benefits on endotherms by optimizing both innate and adaptive immunity. Ectotherms achieve thermoregulation using behavioral strategies, but existing evidence supports its enhancement effect on innate immunity only. Therefore, it remains unknown whether the coordination between fever and adaptive immunity was independently acquired by endotherms or instead represents a gradually evolved function common to vertebrates.
View Article and Find Full Text PDFSolar radiation is an important environmental variable for terrestrial animals, but its impact on the heat balance of large flying insects has been poorly studied. Desert bees are critical to ecosystem function through their pollination services and are exposed to high radiant loads. We assessed the role of solar radiation in the heat balance of flying desert Centris pallida bees by calculating heat budgets for individuals in a respirometer in shaded versus sunny conditions from 16 to 37 ˚C air temperatures, comparing the large and small male morphs and females.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Laboratory of New Antitumor Drug Molecular Design & Synthesis, College of Basic Medicine, Jining Medical University, Jining 272067, Shandong Province, China. Electronic address:
Graphene oxide‑gold nanocomposites (GO-AuNCPs) are promising candidates in nanomedicine. They will inevitably bind with biomolecules such as serum albumin (SA) in the body while they enter the organism. The interaction between GO-AuNCPs and human serum albumin (HSA)/bovine serum albumin (BSA) were investigated by using multispectroscopic methods, elucidating the binding principles through molecular simulations.
View Article and Find Full Text PDFBioessays
November 2024
Division of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, Okazaki, Japan.
Environ Sci Pollut Res Int
December 2024
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Biomass-derived biochar has enormous potential for sustainable and low-cost treatment of lead-contained wastewater. In this study, corncob and cow dung-derived biochar were prepared. The increase in pyrolysis temperature could improve the porous structures, surface area, functional groups and alkalinity, and further provide a higher Pb capacity in both biochars.
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